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Cat. No.: HY-W741686

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1-Oleoyl-2-DHA-PC

Name: 1-Oleoyl-2-DHA-PC
Brand: MedChemExpress
SKU: HY-W741686
Availability: PreOrder

(Synonyms: 1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine)

1-Oleoyl-2-DHA-PC (1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine) is a 5-lipoxygenase inhibitor with an ID₅₀ of 4.0 μM. It inhibits the conversion of arachidonic acid (HY-109590) to 5-HETE in a non-competitive manner and maintains membrane fluidity under high hydrostatic pressure through conformational disorder conferred by multiple cis double bonds. 1-Oleoyl-2-DHA-PC is used in lipoxygenase-related research and membrane biophysics studies.

For research use only. We do not sell to patients.

CAS No.: 99296-82-9
Formula: C₄₈H₈₂NO₈P
Molecular Weight:832.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

1-Oleoyl-2-DHA-PC Chemical Structure

CAS No.: 99296-82-9

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Biological Activity

Description

IC₅₀ & Target

^[1]

5-LOX

4.0 μM (ID₅₀)

All Lipoxygenase Isoforms :

In Vitro

1-Oleoyl-2-DHA-PC (15 min) is the most potent inhibitor of 5-Lipoxygenase in RBL-1 cells, with an ID₅₀ of 4.0 μM^[1].
1-Oleoyl-2-DHA-PC (7.2 μM) non-competitively inhibits 5-Lipoxygenase in RBL-1 cell supernatants, decreasing V_max without significantly affecting K_m^[1].
1-Oleoyl-2-DHA-PC (1-1500 bar; 250 ns) maintains pressure-insensitive fluidity and a stable area compressibility modulus across the 1-1500 bar range, retaining approximately 40% of its 1 bar fluidity at 1500 bar^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 99296-82-9
Molecular Weight 832.14
Formula C₄₈H₈₂NO₈P
SMILES

CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OC(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Synonyms

1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Matsumoto K, et al. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. Prostaglandins Leukot Essent Fatty Acids. 1993 Nov;49(5):861-6.

[2]. Peng Tao, et al. Bio-inspired hybrid flexible composites for deep-sea pressure resistance: A molecular dynamics study.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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1-Oleoyl-2-DHA-PC

All Lipoxygenase Isoforms

Biological Activity

Description

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