99296-82-9
Chemical Structure
1-Oleoyl-2-DHA-PC
Synonym(s): 1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine
- CAS No.: 99296-82-9
- Formula:C48H82NO8P
- Molecular Weight:832.14
IUPAC Name: (R)-2-(((4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoyl)oxy)-3-(oleoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: FPEVDFOXMCHLKL-MIIHFGKESA-N
SMILES: CC/C=C\C/C=C\C/C=C\C/C=C\C/C=C\C/C=C\CCC(OC(COC(CCCCCCC/C=C\CCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O)=O
Biological Activity: 1-Oleoyl-2-DHA-PC (1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine) is a 5-lipoxygenase inhibitor with an ID50 of 4.0 μM. It inhibits the conversion of arachidonic acid (HY-109590) to 5-HETE in a non-competitive manner and maintains membrane fluidity under high hydrostatic pressure through conformational disorder conferred by multiple cis double bonds. 1-Oleoyl-2-DHA-PC is used in lipoxygenase-related research and membrane biophysics studies[1][2].
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1-Oleoyl-2-DHA-PC | 1-Oleoyl-2-DHA-PC (1-Oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine) is a 5-lipoxygenase inhibitor with an ID50 of 4.0 μM. It inhibits the conversion of arachidonic acid (HY-109590) to 5-HETE in a non-competitive manner and maintains membrane fluidity under high hydrostatic pressure through conformational disorder conferred by multiple cis double bonds. 1-Oleoyl-2-DHA-PC is used in lipoxygenase-related research and membrane biophysics studies. | |||||||||||||||||||||
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References
- [1]. Matsumoto K, et al. Inhibitory effect of docosahexaenoic acid-containing phospholipids on 5-lipoxygenase in rat basophilic leukemia cells. Prostaglandins Leukot Essent Fatty Acids. 1993 Nov;49(5):861-6.
- [2]. Peng Tao, et al. Bio-inspired hybrid flexible composites for deep-sea pressure resistance: A molecular dynamics study.
