2. Cell Cycle/DNA Damage
  3. Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
  4. 2'-O,4'-C-Methyleneadenosine

2'-O,4'-C-Methyleneadenosine  (Synonyms: LNA-A)

Cat. No.: HY-110407 Pureza: 99.92%
COA
SDS
Instrucciones de manejo Technical Support

2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog.

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2'-O,4'-C-Methyleneadenosine

2'-O,4'-C-Methyleneadenosine Estructura química

No. CAS : 206055-70-1

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2'-O,4'-C-Methyleneadenosine Related Antibodies

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Descripciòn

2'-O,4'-C-Methyleneadenosine (LNA-A) is a locked nucleic acid (LNA) and is also an adenosine analog[1].

Cellular Effect
Cell Line Type Value Description References
Huh-7 EC50
> 50 μM
Compound: 4
Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
[PMID: 24815510]
Peso molecular

279.26

Fòrmula

C11H13N5O4
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C(N=CN=C4N)=C4N=C3)O1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvente y solubilidad
In Vitro: 

DMSO : 10 mg/mL (35.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5809 mL 17.9045 mL 35.8089 mL
5 mM 0.7162 mL 3.5809 mL 7.1618 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.92%

SDS (393 KB)

COA (255 KB) HNMR (253 KB) RP-HPLC (234 KB) MS (70 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5809 mL 17.9045 mL 35.8089 mL 89.5223 mL
5 mM 0.7162 mL 3.5809 mL 7.1618 mL 17.9045 mL
10 mM 0.3581 mL 1.7904 mL 3.5809 mL 8.9522 mL
15 mM 0.2387 mL 1.1936 mL 2.3873 mL 5.9682 mL
20 mM 0.1790 mL 0.8952 mL 1.7904 mL 4.4761 mL
25 mM 0.1432 mL 0.7162 mL 1.4324 mL 3.5809 mL
30 mM 0.1194 mL 0.5968 mL 1.1936 mL 2.9841 mL
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2'-O,4'-C-Methyleneadenosine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-O,4'-C-Methyleneadenosine206055-70-1LNA-ANucleoside Antimetabolite/AnalogDNA/RNA Synthesislocked nucleic acidLNAadenosine analogInhibitorinhibitorinhibit

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Nombre del producto:
2'-O,4'-C-Methyleneadenosine
Cat. No.:
HY-110407
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