2'-O,4'-C-Methylenecytidine
Based on 1 Customer Validation
2'-O,4'-C-Methylenecytidine (LNA-C(Bz)) is a bicyclic nucleoside analogue with fixed N-type conformation. 2'-O,4'-C-Methylenecytidine can be used to synthesize oligonucleotides. 2'-O,4'-C-Methylenecytidine forms duplexes with complementary DNA and RNA strands.
For research use only. We do not sell to patients.
- Purity: 98.59%
- CAS No.: 206055-69-8
- Formula: C10H13N3O5
- Molecular Weight:255.23
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | EC50 |
>50 μM
Compound: 5
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Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
Antiviral activity against wild type Hepatitis C virus genotype 1b infected in human HuH7 cells after 72 hrs by luciferase reporter gene assay
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[PMID: 24815510] |
Chemical Information
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CAS No. 206055-69-8
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Appearance Solid
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Molecular Weight 255.23
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Formula C10H13N3O5
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Color White to off-white
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SMILES
OC[C@]1(CO2)[C@@H](O)[C@@H]2[C@H](N3C=CC(N)=NC3=O)O1
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Synonyms
LNA-C(Bz)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (391.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9180 mL | 19.5902 mL | 39.1803 mL | 97.9509 mL |
| 5 mM | 0.7836 mL | 3.9180 mL | 7.8361 mL | 19.5902 mL | |
| 10 mM | 0.3918 mL | 1.9590 mL | 3.9180 mL | 9.7951 mL | |
| 15 mM | 0.2612 mL | 1.3060 mL | 2.6120 mL | 6.5301 mL | |
| 20 mM | 0.1959 mL | 0.9795 mL | 1.9590 mL | 4.8975 mL | |
| 25 mM | 0.1567 mL | 0.7836 mL | 1.5672 mL | 3.9180 mL | |
| 30 mM | 0.1306 mL | 0.6530 mL | 1.3060 mL | 3.2650 mL | |
| 40 mM | 0.0980 mL | 0.4898 mL | 0.9795 mL | 2.4488 mL | |
| 50 mM | 0.0784 mL | 0.3918 mL | 0.7836 mL | 1.9590 mL | |
| 60 mM | 0.0653 mL | 0.3265 mL | 0.6530 mL | 1.6325 mL | |
| 80 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2244 mL | |
| 100 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9795 mL |
2'-O,4'-C-Methylenecytidine Related Classifications
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