1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. 3-Methyl-2-oxobutanoic acid

3-Methyl-2-oxobutanoic acid 

Cat. No.: HY-W006057 Purity: 99.10%
Handling Instructions

3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.

For research use only. We do not sell to patients.

3-Methyl-2-oxobutanoic acid Chemical Structure

3-Methyl-2-oxobutanoic acid Chemical Structure

CAS No. : 759-05-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
100 mg USD 70 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

3-Methyl-2-oxobutanoic acid is a precursor of pantothenic acid in Escherichia coli.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) is a precursor of pantothenic acid in Escherichia coli[1]. 3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) enhances alpha-ketoisocaproic acid and alpha-keto-beta-methyl-n-valeric acid, but diminishes the corresponding amino acids, and causes an early decline of ornithine along with a late augmentation of plasma arginine[2].

In Vivo

3-Methyl-2-oxobutanoic acid (alpha-Ketoisovaleric acid) induces convulsions through GABAergic and glutamatergic mechanisms in rats[3].

Molecular Weight

116.12

Formula

C₅H₈O₃

CAS No.

759-05-7

SMILES

CC(C)C(C(O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (1076.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 8.6118 mL 43.0589 mL 86.1178 mL
5 mM 1.7224 mL 8.6118 mL 17.2236 mL
10 mM 0.8612 mL 4.3059 mL 8.6118 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.17 mg/mL (18.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.17 mg/mL (18.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.17 mg/mL (18.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.10%

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Keywords:

3-Methyl-2-oxobutanoic acidEndogenous MetaboliteInhibitorinhibitorinhibit

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Product Name:
3-Methyl-2-oxobutanoic acid
Cat. No.:
HY-W006057
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