3-Chloroiminodibenzyl
Based on 1 Customer Validation
3-Chloroiminodibenzyl (compound 8) is a dual inhibitor of sHE and 5-LOX. 3-Chloroiminodibenzyl inhibits sHE and 5-LOX with IC50 of 140 μM and 6.5 μM, respectively.
For research use only. We do not sell to patients.
- Purity: 99.60%
- CAS No.: 32943-25-2
- Formula: C14H12ClN
- Molecular Weight:229.70
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Storage:
Store at room temperature 3 years.
In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
sHE, 5-LOX[1]
Chemical Information
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CAS No. 32943-25-2
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Appearance Solid
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Molecular Weight 229.70
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Formula C14H12ClN
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Color White to off-white
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SMILES
ClC1=CC2=C(C=C1)CCC3=CC=CC=C3N2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Store at room temperature 3 years
In solvent -80°C 2 years -20°C 1 year
Solvent & Solubility
DMSO : 100 mg/mL (435.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.3535 mL | 21.7675 mL | 43.5350 mL | 108.8376 mL |
| 5 mM | 0.8707 mL | 4.3535 mL | 8.7070 mL | 21.7675 mL | |
| 10 mM | 0.4354 mL | 2.1768 mL | 4.3535 mL | 10.8838 mL | |
| 15 mM | 0.2902 mL | 1.4512 mL | 2.9023 mL | 7.2558 mL | |
| 20 mM | 0.2177 mL | 1.0884 mL | 2.1768 mL | 5.4419 mL | |
| 25 mM | 0.1741 mL | 0.8707 mL | 1.7414 mL | 4.3535 mL | |
| 30 mM | 0.1451 mL | 0.7256 mL | 1.4512 mL | 3.6279 mL | |
| 40 mM | 0.1088 mL | 0.5442 mL | 1.0884 mL | 2.7209 mL | |
| 50 mM | 0.0871 mL | 0.4354 mL | 0.8707 mL | 2.1768 mL | |
| 60 mM | 0.0726 mL | 0.3628 mL | 0.7256 mL | 1.8140 mL | |
| 80 mM | 0.0544 mL | 0.2721 mL | 0.5442 mL | 1.3605 mL | |
| 100 mM | 0.0435 mL | 0.2177 mL | 0.4354 mL | 1.0884 mL |
3-Chloroiminodibenzyl Related Classifications
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