1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. GLUT
    Endogenous Metabolite
  3. 4,6-O-Ethylidene-α-D-glucose

4,6-O-Ethylidene-α-D-glucose (Synonyms: Ethylidene-glucose)

Cat. No.: HY-N7433
Handling Instructions

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport.

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4,6-O-Ethylidene-α-D-glucose Chemical Structure

4,6-O-Ethylidene-α-D-glucose Chemical Structure

CAS No. : 13224-99-2

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Description

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport[1][2][3].

IC50 & Target[1]

GLUT1

 

Human Endogenous Metabolite

 

In Vitro

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; Ki>50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a Ki of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant[1].
4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound[3].

Molecular Weight

206.19

Formula

C₈H₁₄O₆

CAS No.

13224-99-2

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Keywords:

4,6-O-Ethylidene-α-D-glucoseEthylidene-glucoseGLUTEndogenous MetaboliteGlucose transporterglucosederivativecompetitiveexofacialbinding-sitetransporter1GLUT12-deoxy-D-glucosetransportInhibitorinhibitorinhibit

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4,6-O-Ethylidene-α-D-glucose
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HY-N7433
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