1. Membrane Transporter/Ion Channel
    Metabolic Enzyme/Protease
  2. GLUT
    Endogenous Metabolite
  3. 4,6-O-Ethylidene-α-D-glucose

4,6-O-Ethylidene-α-D-glucose (Synonyms: Ethylidene-glucose)

Cat. No.: HY-N7433 Purity: >98.0%
Handling Instructions

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport.

For research use only. We do not sell to patients.

4,6-O-Ethylidene-α-D-glucose Chemical Structure

4,6-O-Ethylidene-α-D-glucose Chemical Structure

CAS No. : 13224-99-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 110 In-stock
Estimated Time of Arrival: December 31
50 mg USD 100 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
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Description

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose), a glucose derivative, is a competitive exofacial binding-site inhibitor on glucose transporter 1 (GLUT1) with a Ki of 12 mM for wild-type 2-deoxy-D-glucose transport[1][2][3].

IC50 & Target[1]

GLUT1

 

Human Endogenous Metabolite

 

In Vitro

4,6-O-ethylidene-α-D-glucose (Ethylidene-glucose) shows poor affinity for malarial hexose transporter (PfHT1; Ki>50 mM). 4,6-O-ethylidene-α-D-glucose inhibits wild-type transport with a Ki of approximately 12 mM, but this is increased to greater than 120 mM in the Gln282-Leu mutant[1].
4,6-O-ethylidene-α-D-glucose inhibits glucose exit competitively but its penetration into human red cells is unaffected by glucose in the medium. The potentiation of the development of FDNB inhibition by sugars in the incubating medium is absent when 4,6-O-ethylidene-α-D-glucose is used and there is a slight protective action. 4,6-O-ethylidene-α-D-glucose penetrates human red cells by simple diffusion supported by its penetration of guinea-pig red cells at similar rates, by the occurrence of osmotic haemolysis in isosmotic solutions which is unaffected by copper ions and by the relatively high ether/water partition of the compound[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

206.19

Formula

C₈H₁₄O₆

CAS No.

13224-99-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (606.24 mM; Need ultrasonic)

DMSO : 100 mg/mL (484.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8499 mL 24.2495 mL 48.4990 mL
5 mM 0.9700 mL 4.8499 mL 9.6998 mL
10 mM 0.4850 mL 2.4249 mL 4.8499 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (12.12 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

4,6-O-Ethylidene-α-D-glucoseEthylidene-glucoseGLUTEndogenous MetaboliteGlucose transporterglucosederivativecompetitiveexofacialbinding-sitetransporter1GLUT12-deoxy-D-glucosetransportInhibitorinhibitorinhibit

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Product Name:
4,6-O-Ethylidene-α-D-glucose
Cat. No.:
HY-N7433
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