4-Chloro-7H-pyrrolo[2,3-d]pyrimidine 

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is a nitrogen-containing heterocyclic organic synthesis intermediate that can be used for the synthesis of JAK and PKB/Akt inhibitors^[1][2].

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is widely used as a pyrimidine/purine bioisostere core scaffold for kinase inhibitors^[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

153.57

C₆H₄ClN₃

3680-69-1

Solid

White to light brown

ClC1=C2C(NC=C2)=NC=N1

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Liu Y, et al. Discovery of 4-(Piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine Derivatives as Akt Inhibitors. Arch Pharm (Weinheim). 2016 May;349(5):356-62.
  

  [2]. Caldwell JJ, et al. Identification of 4-(4-aminopiperidin-1-yl)-7 H-pyrrolo [2, 3-d] pyrimidines as selective inhibitors of protein kinase B through fragment elaboration. Journal of medicinal chemistry. 2008 Apr 10;51(7):2147-57.