1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. 5-Carboxamidotryptamine maleate

5-Carboxamidotryptamine maleate (Synonyms: 5-CT maleate)

Cat. No.: HY-100942
Handling Instructions

5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist.

For research use only. We do not sell to patients.

5-Carboxamidotryptamine maleate Chemical Structure

5-Carboxamidotryptamine maleate Chemical Structure

CAS No. : 74885-72-6

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Description

5-Carboxamidotryptamine maleate (5-CT maleate) is a potent 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 receptors agonist[1][2][3].

IC50 & Target[3]

5-HT1A Receptor

 

5-HT1B Receptor

 

5-HT1D Receptor

 

5-HT5 Receptor

 

5-HT7 Receptor

 

In Vitro

[3H]-5-Carboxamidotryptamine (5-CT) binding to 5-HT1D sites in bovine substantia nigra is rapid, reversible and saturable, displaying high affinity (Kd = 0.38 nM) and low non-specific binding[2].
In bovine substantia nigra, [3H]-5-Carboxamidotryptamine (5-CT) labelled an equivalent number of binding sites to [3H]-5-Carboxamidotryptamine (403 and 362 fmol/mg protein, respectively) and binding is sensitive to guanine nucleotides[2].

In Vivo

Topical 5-Carboxamidotryptamine (0.01-1000 μM) to the exposed dura mater encephala produced decreases in diastolic blood pressure, variable changes in meningeal blood flow and increases in conductance (i.e. dilatation) in the middle meningeal artery of anesthetized Wistar rats (serotonin depletion and treated with 20 mg/kg corticosterone)[1].

Molecular Weight

319.31

Formula

C₁₅H₁₇N₃O₅

CAS No.

74885-72-6

SMILES

O=C(C1=CC2=C(NC=C2CCN)C=C1)N.O=C(O)/C=C\C(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

5-Carboxamidotryptamine5-CT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT1A5-HT1B5-HT1D5-HT55-HT7migraineserotonincorticosteroneguanineInhibitorinhibitorinhibit

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5-Carboxamidotryptamine maleate
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HY-100942
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