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Cat. No.: HY-187537

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5-HT2AR ligand-2

5-HT2AR ligand-2 is a serotonin 2A receptor (5-HT_2AR) ligand with a K_i value of 11.4 nM. 5-HT2AR ligand-2 stabilizes the inactive conformation of receptors by interacting with specific amino acid residues in the orthosteric binding pockets of D₂R and 5-HT_2AR, thereby blocking downstream signal transduction. 5-HT2AR ligand-2 can be used in studies related to schizophrenia.

For research use only. We do not sell to patients.

Formula: C₂₅H₂₇F₂N₃O
Molecular Weight:423.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5-HT2AR ligand-2 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

5-HT2AR

All 5-HT Receptor Isoforms :

In Vitro

5-HT2AR ligand-2 (Compound 35) (0.1 nM-10 μM; 90 min) exhibits specific binding activity to 5-HT_2AR in membrane fragments of cells stably expressing the specific receptor (including CHO, HEK T*, HET T, fibroblast), with a Ki value of 11.4 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5-HT2AR ligand-2 (Compound 35) (intraperitoneal injection; single administration) exerts an inhibitory effect on abnormal climbing behavior in the apomorphine (HY-12723)-induced climbing mouse model^[1].
SYA16263 (5.91-17.73 mg/kg; i.p.; single administration; 60-66 min) does not induce extrapyramidal side effects in the rat catalepsy test model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (male, ~ 6 weeks old, 133-153 g)^[1]
Dosage:

5.91 mg/kg, 11.82 mg/kg, 17.73 mg/kg
Administration:

i.p.; single administration; 60, 63, 66 min
Result:

Showed no significant cataleptic response in either the bar test or CLP test across all doses compared with vehicle controls.
Enabled all animals to successfully right themselves during the righting reflex test, indicating no marked impairment.

Chemical Information

Molecular Weight 423.50
Formula C₂₅H₂₇F₂N₃O
SMILES

OC(C1=CC=C(F)C=C1)(CCCN2CCN(C3=NC=CC=C3)CC2)C4=CC=C(F)C=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gonela UM, et al. Structure-Affinity Relationship Optimization of SYA16263 Yields New Ligands with Improved Receptor Affinity and Antipsychotic-Like Properties. ACS Omega. 2026 Jul 20;11(31):46009-46029.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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5-HT2AR ligand-2

All 5-HT Receptor Isoforms