CB30865 (Synonyms: ZM 242421)

Name: CB30865
Brand: MedChemExpress
SKU: HY-14373
Rating: 4.5 (1 reviews)

Cat. No.: HY-14373 Purity: 98.75%: Data Sheet
COA

SDS
Handling Instructions
FAQs
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CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range). CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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CB30865 화학구조

CAS No. : 206275-15-2

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
25 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	해외재고보유	Estimated Time of Arrival: December 31
100 mg	해외재고보유	Estimated Time of Arrival: December 31
200 mg	견적 받기
500 mg	견적 받기

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

CB30865 (ZM 242421) is a nicotinamide phosphoribosyltransferase (Nampt) inhibitor, with potent cytotoxicity. CB30865 is highly potent against a variety of human tumour cell lines (IC₅₀ values in the 1-10 nM range)^[1]^[2]. CB30865 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cellular Effect

Cell Line	Type	Value	Description	References
WIL2	EC₅₀	2.8 nM Compound: 1, CB-30865	Cytotoxicity against human W1L2 cells Cytotoxicity against human W1L2 cells	[PMID: 21080724]
WIL2	EC₅₀	2.8 nM Compound: 20, CB-30865	Cytotoxicity against human W1L2 cells Cytotoxicity against human W1L2 cells	[PMID: 23679915]
WIL2	IC₅₀	2.2 nM Compound: CB-30685	Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 uM thymidine/50 uM hypoxanthine Growth inhibitory activity against human lymphoblastoid W1L2 cell line in presence of 10 uM thymidine/50 uM hypoxanthine	[PMID: 12166942]
WIL2	IC₅₀	2.8 nM Compound: CB-30685	Growth inhibitory activity against human lymphoblastoid W1L2 cell line Growth inhibitory activity against human lymphoblastoid W1L2 cell line	[PMID: 12166942]
WIL2	IC₅₀	2.8 nM Compound: CB30865	Cytotoxicity against human W1L2 cells assessed as growth inhibition after 72 hrs by trypan blue assay Cytotoxicity against human W1L2 cells assessed as growth inhibition after 72 hrs by trypan blue assay	[PMID: 24164086]

In Vitro

CB30865 exhibits cytotoxicity due to NAD reduction via Nampt inhibition^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

516.39

화학식

C₂₆H₂₂BrN₅O₂

CAS No.

206275-15-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=CN=C1)C2=CC=C(N(CC3=CC4=C(N=C(C)NC4=O)C=C3Br)CC#C)C=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

용액&용해도

In Vitro:

DMSO : 33.33 mg/mL (64.54 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9365 mL	9.6826 mL	19.3652 mL
5 mM	0.3873 mL	1.9365 mL	3.8730 mL
10 mM	0.1937 mL	0.9683 mL	1.9365 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98.75%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (254 KB) RP-HPLC (86 KB)

Handling Instructions (2659 KB)

References

[1]. Fleischer TC, et al. Chemical proteomics identifies Nampt as the target of CB30865, an orphan cytotoxic compound. Chem Biol. 2010 Jun 25;17(6):659-664. [Content Brief]

[2]. Skelton LA, et al. Cell cycle effects of CB30865, a lipophilic quinazoline-based analogue of the antifolate thymidylate synthase inhibitor ICI 198583 with an undefined mechanism of action. Cytometry. 1998 Sep 1;33(1):56-66. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9365 mL	9.6826 mL	19.3652 mL	48.4130 mL
	5 mM	0.3873 mL	1.9365 mL	3.8730 mL	9.6826 mL
	10 mM	0.1937 mL	0.9683 mL	1.9365 mL	4.8413 mL
	15 mM	0.1291 mL	0.6455 mL	1.2910 mL	3.2275 mL
	20 mM	0.0968 mL	0.4841 mL	0.9683 mL	2.4207 mL
	25 mM	0.0775 mL	0.3873 mL	0.7746 mL	1.9365 mL
	30 mM	0.0646 mL	0.3228 mL	0.6455 mL	1.6138 mL
	40 mM	0.0484 mL	0.2421 mL	0.4841 mL	1.2103 mL
	50 mM	0.0387 mL	0.1937 mL	0.3873 mL	0.9683 mL
	60 mM	0.0323 mL	0.1614 mL	0.3228 mL	0.8069 mL

CB30865 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CB30865 (Synonyms: ZM 242421)

고객리뷰

CB30865 Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

순도&문서

References

고객리뷰

CB30865 Related Antibodies

몰농도 계산기

농도 희석 계산기

Complete Stock Solution Preparation Table

CB30865 Related Classifications

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고객리뷰

Request for HNMR Report

SAFETY DATA SHEET (SDS)

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