1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl

DPH 

Cat. No.: HY-12070 Purity: 98.41%
Data Sheet SDS Handling Instructions

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

For research use only. We do not sell to patients.
DPH Chemical Structure

DPH Chemical Structure

CAS No. : 484049-04-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $134 In-stock
10 mg $122 In-stock
50 mg $490 In-stock
100 mg   Get quote  
200 mg   Get quote  

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    DPH purchased from MCE. Usage Cited in: Mol Cell Neurosci. 2017 Oct 26;85:226-234.

    In a separate experiment, mice are injected with DPH and euthanized 4 hours later. DPH increases hippocampal p190RhoGAP phosphorylation. Representative blots below.

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    • Biological Activity

    • Protocol

    • Technical Information

    • Purity & Documentation

    • References

    Description

    DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

    In Vitro

    DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].

    References
    Preparing Stock Solutions
    Concentration Volume Mass 1 mg 5 mg 10 mg
    1 mM 2.9734 mL 14.8668 mL 29.7336 mL
    5 mM 0.5947 mL 2.9734 mL 5.9467 mL
    10 mM 0.2973 mL 1.4867 mL 2.9734 mL
    Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    336.32

    Formula

    C₁₈H₁₃FN₄O₂

    CAS No.

    484049-04-9

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    DPH is suspended in 17% DMSO and PBS[2].

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    References

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    DPH
    Cat. No.:
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