1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl
  3. DPH

DPH 

Cat. No.: HY-12070 Purity: 98.83%
Handling Instructions

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

For research use only. We do not sell to patients.

DPH Chemical Structure

DPH Chemical Structure

CAS No. : 484049-04-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 161 In-stock
Estimated Time of Arrival: December 31
10 mg USD 146 In-stock
Estimated Time of Arrival: December 31
50 mg USD 588 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    DPH purchased from MCE. Usage Cited in: Mol Cell Neurosci. 2017 Dec;85:226-234.

    In a separate experiment, mice are injected with DPH and euthanized 4 hours later. DPH increases hippocampal p190RhoGAP phosphorylation. Representative blots below.

    DPH purchased from MCE. Usage Cited in: Toxicol Sci. 2018 Sep 1;165(1):232-243.

    Treatment of SN4741 cells with DPH, a c-Abl activator, results in a significant phosphorylation of GSK3β-Y216
    • Biological Activity

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    Description

    DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

    In Vitro

    DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].

    Molecular Weight

    336.32

    Formula

    C₁₈H₁₃FN₄O₂

    CAS No.

    484049-04-9

    SMILES

    O=C1NC(C(N1)C2=CN(N=C2C3=CC=C(C=C3)F)C4=CC=CC=C4)=O

    Shipping

    Room temperature in continental US; may vary elsewhere

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (297.34 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9734 mL 14.8668 mL 29.7336 mL
    5 mM 0.5947 mL 2.9734 mL 5.9467 mL
    10 mM 0.2973 mL 1.4867 mL 2.9734 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.43 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 98.83%

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    This equation is commonly abbreviated as: C1V1 = C2V2

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    Product Name:
    DPH
    Cat. No.:
    HY-12070
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