1. Protein Tyrosine Kinase/RTK
  2. Bcr-Abl

DPH 

Cat. No.: HY-12070
Handling Instructions

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

For research use only. We do not sell to patients.
DPH Chemical Structure

DPH Chemical Structure

CAS No. : 484049-04-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $134 In-stock
10 mg $122 In-stock
50 mg $490 In-stock
100 mg   Get quote  
200 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

DPH is a potent cell permeable c-Abl activator, which displays potent enzymatic and cellular activity in stimulating c-Abl activation.  

In Vitro

DPH binds to the myristoyl binding site and prevents the formation of the bent conformation of the αI helix through steric hindrance, a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site. DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation[1].

References
Preparing Stock Solutions
Concentration Volume (DMSO) Mass 1 mg 5 mg 10 mg
1 mM 2.9734 mL 14.8668 mL 29.7336 mL
5 mM 0.5947 mL 2.9734 mL 5.9467 mL
10 mM 0.2973 mL 1.4867 mL 2.9734 mL
References
Molecular Weight

336.32

Formula

C₁₈H₁₃FN₄O₂

CAS No.

484049-04-9

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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DPH
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