(S,R,S)-AHPC-PEG2-NH2
Based on 1 Customer Validation
(S,R,S)-AHPC-PEG2-NH2 (VH032-PEG2-NH2) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in the synthesis of PROTACs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.06%
- CAS 番号: 2010159-60-9
- 分子式: C28H41N5O6S
- 分子量:575.72
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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HY-103602
(S,R,S)-AHPC-PEG3-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugate -
HY-103604A
(S,R,S)-AHPC-PEG4-NH2E3 ligase ligand-linker conjugate -
HY-103604
(S,R,S)-AHPC-PEG4-NH2 hydrochlorideE3 ligase ligand-linker conjugate -
HY-101763A
(S,R,S)-AHPC monohydrochlorideVHL Ligand -
HY-114176
(S,R,S)-AHPC-C4-NH2 hydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-133487B
(S,R,S)-AHPC-C8-NH2E3 Ligase Ligand-Linker Conjugate -
HY-136008
(S,R,S)-AHPC-PEG1-NH2 -
HY-136163
(S,R,S)-AHPC-C2-NH2 dihydrochlorideE3 Ligase Ligand-Linker Conjugates -
HY-103603AR
(S,R,S)-AHPC-PEG2-NH2 (Standard)Reference Standard -
HY-103602A
(S,R,S)-AHPC-PEG3-NH2 -
HY-103601
(S,R,S)-AHPC-PEG4-N3E3 ligase ligand-linker conjugate -
HY-103600
(S,R,S)-AHPC-PEG1-N3E3 Ligase Ligand-Linker Conjugate
E3 Ligase Ligand-Linker Conjugates アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
IC50 & Target
[1]|
VHL |
体外実験
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2010159-60-9
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性状 Solid
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分子量 575.72
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分子式 C28H41N5O6S
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Color Off-white to light yellow
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SMILES
O=C([C@H]1N(C([C@@H](NC(COCCOCCN)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC2=CC=C(C3=C(C)N=CS3)C=C2
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別名
VH032-PEG2-NH2 ; VHL Ligand-Linker Conjugates 3 ; E3 ligase Ligand-Linker Conjugates 6 Free Base
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (173.70 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7370 mL | 8.6848 mL | 17.3696 mL | 43.4239 mL |
| 5 mM | 0.3474 mL | 1.7370 mL | 3.4739 mL | 8.6848 mL | |
| 10 mM | 0.1737 mL | 0.8685 mL | 1.7370 mL | 4.3424 mL | |
| 15 mM | 0.1158 mL | 0.5790 mL | 1.1580 mL | 2.8949 mL | |
| 20 mM | 0.0868 mL | 0.4342 mL | 0.8685 mL | 2.1712 mL | |
| 25 mM | 0.0695 mL | 0.3474 mL | 0.6948 mL | 1.7370 mL | |
| 30 mM | 0.0579 mL | 0.2895 mL | 0.5790 mL | 1.4475 mL | |
| 40 mM | 0.0434 mL | 0.2171 mL | 0.4342 mL | 1.0856 mL | |
| 50 mM | 0.0347 mL | 0.1737 mL | 0.3474 mL | 0.8685 mL | |
| 60 mM | 0.0289 mL | 0.1447 mL | 0.2895 mL | 0.7237 mL | |
| 80 mM | 0.0217 mL | 0.1086 mL | 0.2171 mL | 0.5428 mL | |
| 100 mM | 0.0174 mL | 0.0868 mL | 0.1737 mL | 0.4342 mL |
(S,R,S)-AHPC-PEG2-NH2 関連分類
HY-103603A 関連分類
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