2. L-Moses

L-Moses  (Synonyms: L-45)

製品番号: HY-101125 純度: ≥99.0%
COA 取扱説明書

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L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM.

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L-Moses 構造式

L-Moses 構造式

CAS 番号 : 2079885-05-3

容量 価格（税別） 在庫状況
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 374 見積もりとリードタイムを求めるのご確認
Solution
10 mM * 1 mL in DMSO USD 374 見積もりとリードタイムを求めるのご確認
Solid
5 mg USD 340 見積もりとリードタイムを求めるのご確認
10 mg USD 550 見積もりとリードタイムを求めるのご確認

* アイテムを追加する前、数量をご選択ください

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Other 在庫あり Forms of L-Moses:

Other Forms of L-Moses:

L-Moses 関連抗体

Top Publications Citing Use of Products

    L-Moses purchased from MedChemExpress. Usage Cited in: EMBO Rep. 2020 Mar 4;21(3):e48328.  [Abstract]

    Inhibiting acetyltransferases CBP/P300 by TPOP146 (134 nM) or PCAF by L-45 (126 nM) for 24 h did not significantly decrease the K49-acetylated b-cat level in Tau-overexpressing N2a cells (n = 3 biological replicates each group)

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    製品説明

    L-Moses (L-45) is the first potent, selective, and cell-active p300/CBP-associated factor (PCAF) bromodomain (Brd) inhibitor with a Kd of 126 nM[1].

    IC50 & Target

    Kd:126±15nM (PCAF Brd-binding)[1]
    体外実験

    L-Moses (L-45) disrupts PCAF-Brd histone H3.3 interaction in cells using a nanoBRET assay, and a co-crystal structure of L-Moses with the homologous Brd PfGCN5 from Plasmodium falciparum rationalizes the high selectivity for PCAF and GCN5 bromodomains. A structure using highly homologous (64 % identity) Brd from Plasmodium falciparum, PfGCN5, of which L-Moses is also a potent ligand (isothermal titration calorimetry (ITC) KD 280 nM), is successfully obtained (PDB: 5TPX). L-Moses binds in the acetylated lysines (KAc) -binding pocket of PfGCN (blue ribbon and sticks) and makes H-bonds (dotted lines) through the triazole to N1436 and the first of a network of four water molecules (red spheres)[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    L-Moses 関連抗体
    体内実験

    L-Moses (L-45) shows no observable cytotoxicity in peripheral blood mononuclear cells (PBMC), good cell-permeability, and metabolic stability in human and mouse liver microsomes, supporting its potential for in vivo use[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    360.46

    分子式

    C21H24N6
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    C[C@@H]([C@H](C1=CC=CC=C1)N(C)C)NC(C2=C3C=CC=C2)=NN4C3=NN=C4C
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 33.33 mg/mL (92.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.7742 mL 13.8712 mL 27.7423 mL
    5 mM 0.5548 mL 2.7742 mL 5.5485 mL
    10 mM 0.2774 mL 1.3871 mL 2.7742 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    純度とドキュメンテーション

    純度: 99.97%

    COA (254 KB) RP-HPLC (225 KB) MS (197 KB)

    取扱説明書 (2659 KB)

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.7742 mL 13.8712 mL 27.7423 mL 69.3558 mL
    5 mM 0.5548 mL 2.7742 mL 5.5485 mL 13.8712 mL
    10 mM 0.2774 mL 1.3871 mL 2.7742 mL 6.9356 mL
    15 mM 0.1849 mL 0.9247 mL 1.8495 mL 4.6237 mL
    20 mM 0.1387 mL 0.6936 mL 1.3871 mL 3.4678 mL
    25 mM 0.1110 mL 0.5548 mL 1.1097 mL 2.7742 mL
    30 mM 0.0925 mL 0.4624 mL 0.9247 mL 2.3119 mL
    40 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7339 mL
    50 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3871 mL
    60 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1559 mL
    80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8669 mL
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    L-Moses2079885-05-3L-45L45L 45Inhibitorinhibitorinhibit

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    製品名:
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    製品番号:
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