2. Natural Products
  3. Plants
  4. Euphorbiaceae
  5. Mallotus philippensis

Mallotus philippensis

Mallotus philippensis (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-18980
    Rottlerin 82-08-6 98.15%
    Rottlerin, a natural product purified from Mallotus Philippinensis, is a specific PKC inhibitor, with IC50 values for PKCδ of 3-6 μM, PKCα,β,γ of 30-42 μM, PKCε,η,ζ of 80-100 μM. Rottlerin acts as a direct mitochondrial uncoupler, and stimulates autophagy by targeting a signaling cascade upstream of mTORC1. Rottlerin induces apoptosis via caspase 3 activation. Rottlerin inhibits HIV-1 integration and Rabies virus (RABV) infection.
    Rottlerin