Infection

HSV-1/HSV-2-IN-2 is a HSV-1, HSV-2 and VV inhibitor with EC₅₀ values of 6.8, 8.9 and 8.9 µM, respectively.
HSV-1/HSV-2-IN-2 shows antiviral activity.

La peptide (LAP) is an internal ribosome entry site (IRES) inhibitor. La peptide efficiently enters cells, blocks binding of cellular transacting factors to viral IRES, followed by inhibiting IRES-mediated translation. La peptide can be used for RNA viruses research, such as hepatitis C (HCV) and poliovirus (PV).

Antibacterial agent 96 (compound 4k) is a potent antibacterial agent. Antibacterial agent 96 shows antitubercular activity against agent-susceptible and multidrug-resistantMycobacterium tuberculosis (M. tuberculosis) strains. Antibacterial agent 96 shows toxicity to HepG2 and Vero cells.

Azelastine-¹³C,d₃ (hydrochloride) is the ¹³C- and deuterium labeled Azelastine hydrochloride. Azelastine-¹³C,d₃ (hydrochloride), an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine-¹³C,d₃ (hydrochloride) can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2.

T3SS-IN-4 (Compound Z-8) is a T3SS inhibitor that can inhibit the expression of Xanthomonas oryzae pv oryzae (X_oo) T3SS-related genes without affecting bacterial growth. T3SS-IN-4 can effectively reduce the hypersensitive response (HR) induced by X_oo in tobacco and lower the pathogenicity of X_oo in rice.

S-27609 is an imidazoquinoline with antiviral and antitumour properties. S-27609 can induce peripheral blood mononuclear cells to produce various cytokines such as interferon-α (IFN-α), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). S-27609 is promising for research of viral infections (e.g., herpes virus) and tumors.

Antibacterial agent 157 (compound B12) is a fungicidal agent. Antibacterial agent 157 can influence the protein synthesis of Botrytis cinerea. Antibacterial agent 157 can be used for gray mold resistance control research.

GSK3839919A is a potent and allosteric HIV-1integrase inhibitor.

1233B is a secondary metabolite from filamentous fungus, Fusarium sp. RK97-94.

Trollisin I is a flavonoid C-glycoside present in the flowers of Trollius chinensis, and it exhibits no significant activity against influenza A and influenza B viruses.

Hs-1 is an antimicrobial peptide displays 80% protection against the dengue-2 virus .

Clindamycin 2,4-diphosphate is a related impurity of Clindamycin phosphate (HY-B1064), a prodrug of Clindamycin (HY-B1455). Clindamycin phosphate inhibits protein synthesis by targeting the bacterial ribosomal 50S subunit.

Lamivudine-13C,15N2,d2 (BCH-189-13C,15N2,d2) is a 13C, 15N, and deuterium labeled Lamivudine (HY-B0250). Lamivudine is an orally active and blood-brain barrier permeable nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine inhibits HIV reverse transcriptase 1 and 2 and hepatitis B virus (HBV) reverse transcriptase.

Complex III-IN-2 (Compd 4d-2) is a complex III inhibitor. Complex III-IN-2 shows antifungal activity with an EC₅₀ of 29.98 mg/L and 29.31 mg/L against sclerotinia sclerotiorum and R. solani, respectively.

HIV-IN-5 (compound 5r) is a potent HIV-1 inhibitor, with an IC₅₀ of 0.16 μM. HIV-IN-5 shows inhibition of HIV DNA-dependent DNA polymerization activity, with an IC₅₀ of 2.18 μM. HIV-IN-5 can bind to NNIBP (NNRTIs (non-nucleoside reverse transcriptase inhibitors) binding pocket) .

PD 140248 hydrochloride is a quinolone broad-spectrum antibacterial agent with good in vitro bacteriostatic activity, especially having a significant inhibitory effect on Gram-positive bacteria.

Ftase inhibitor III is an anion-dependent Farnesyltransferase inhibitor from a phenotypic screen.

Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

BRD4-IN-3 (compound 141) is a potent BRD4 inhibitor with an IC₅₀ of <0.5 µM. BRD4-IN-3 shows cytoxicity for MYC-Raji with an IC₅₀ value of >1 µM.

Walnut leave extract is an extract from the leaves of walnut (Juglans) that has antibacterial and antiparasitic properties.