Infection

Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC₅₀ of 4.475 μM and a K_d of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models.

MK-0608 (Standard) is the analytical standard of MK-0608 (HY-10244). This product is intended for research and analytical applications. MK-0608 is a potent and orally bioavailable inhibitor of HCV replication in vitro with an EC₅₀ of 0.3 μM (EC90=1.3 μM) in the subgenomic-replicon assay.

Melithiazol C is an antibiotic. Melithiazole C is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal agent.

Fluvirucin A2 is an antibiotic against influenza A virus.

Cefixime (trihydrate) (Standard) is the analytical standard of Cefixime (trihydrate). This product is intended for research and analytical applications. Cefixime trihydrate (FR-17027 trihydrate) is an antibiotic and a third generation cephalosporin antibiotic, useful for the treatment of a number of bacterial infections.

Julimycin B2 has anti-Gram-positive bacteria and anti-virus activity and it has effects on ehrman ascites carcinoma in mice.

2-Hydroxygentamicin C2 is an antibiotic of the gentamicin group with anti-Gram-positive and negative bacteria activity.

GPCR antagonist-1 is an orally active G protein-coupled receptor (GPCR) antagonist as well as an insecticide. GPCR antagonist-1 induces intestinal microvillus destruction, reduces microfilarial secretion, increases the proportion of malformed embryos, inhibits nematode motility and L3-stage molting, and exerts L4-stage larvicidal activity. GPCR antagonist-1 can be used for the research of filarial infections.

Lavanduquinocin is a protective agent of nerve cells and has the effect of reducing L-glutamate on cytotoxicity of neuronal hybridoma N18-RE-105 with an ED₅₀ of 15.5 nM.

Mureidomycin B is an antibiotic with anti-Pseudomonas aeruginosa activity.

Chondramide C has anti-candida, Henson yeast, lipids yeast, ball-like yeast and other fungal activities, but has no anti-Gram positive and negative bacteria activities.

RNA polymerase-IN-3 (Compound 28) is a bacterial RNA polymerase (RNAP) inhibitor with antibacterial activity. RNA polymerase-IN-3 inhibits RNA synthesis by competitively blocking the binding of UTP to RNAP (IC₅₀= 0.28 μM). RNA polymerase-IN-3 is promising for research of bacterial infections.

Antibacterial agent 149 (Compd 3j) is a laccase inhibitor with high fungicidal activity and can be used in the study of rice sheath blight.

ABT-072 (Standard) is the analytical standard of ABT-072 (HY-101634). This product is intended for research and analytical applications. ABT-072 is an orally active and potent non-nucleoside HCV NS5B polymerase inhibitor (HCV GT1a EC50=1 nM; HCV GT1b EC50=0.3 nM).

ROS inducer 9 (compound 4e) is an antibacterial agent with a MIC value of 0.25 μg/mL against E. coli. ROS inducer 9 kills bacteria by inhibiting GSH activity and increasing ROS levels. ROS inducer 9 shows low toxicity to erythrocytes and RAW 264.7 cells.

Antibacterial agent 310 (compound 2) is a bis-benzimidazole-derived chelating ligand exhibiting antibacterial activity. Antibacterial agent 310 shows inhibition activity against intracellular viruses. Antibacterial agent can be used for antibacterial research.

Lenapenem (BO-2727) hydrochloride hydrate, a carbapenem antibiotic, has potent antibacterial activity against Gram-positive and Gram-negative bacteria including P. aeruginosa.

Dotriacontanoic acid (Lacceroic acid) is a fatty acid found in Limnophila polystachya Benth. Dotriacontanoic acid exhibits anti-bacterial activity against multiple gram-negative bacteria.

DfrA1-IN-1 (Compound DC6) is an orally active DfrA1 inhibitor with strong binding ability to DfrA1. DfrA1-IN-1 can be used in research related to trimethoprim-resistant bacterial infections.

3'-O-Methylguanosine (Standard) is an analytical standard of 3'-O-Methylguanosine (HY-W091784). This product is intended for research and analytical applications. 3'-O-Methylguanosine is a methylated nucleoside analog and RNA chain terminator. 3'-O-Methylguanosine can inhibit the synthesis of early vaccinia virus-specific RNA.