Androgen Receptor
Androgen receptor (AR) is a type of nuclear receptor that is activated by binding of either of the androgenic hormones testosterone or dihydrotestosterone in the cytoplasm and then translocating into the nucleus. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor. The main function of the androgen receptor is as a DNA-binding transcription factor that regulates gene expression. Androgen regulated genes are critical for the development and maintenance of the male sexual phenotype. Mutations in this gene are also associated with complete androgen insensitivity (CAIS).
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Androgen Receptor Inhibitors
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Androgen Receptor Agonists
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Androgen Receptor Antagonists
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Androgen Receptor Ligands
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Androgen Receptor Related Products (480)
Related Products (480)
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Recombinant Proteins (1)
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Antibodies (2)
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N-Nitrosodicyclohexylamine (Standard)
0 ImagesCat. No.: HY-W653723RCAS No.: 947-92-2Synonyms: NDCHA (Standard)N-Nitrosodicyclohexylamine (Standard) is the analytical standard of N-Nitrosodicyclohexylamine. This product is intended for research and analytical applications. N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein.
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Allylestrenol (Standard)
0 ImagesAllylestrenol (Standard) is the analytical standard of Allylestrenol. This product is intended for research and analytical applications. Allylestrenol is an orally active synthetic anti-androgen sexualsteroid. Allylestrenol can prevent miscarriage in vivo. Allylestrenol significantly affects testosterone progesterone level in rat model. Allylestrenol can reduce ventral prostate weight in rat model.
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11-Ketodihydrotestosterone (Standard)
0 ImagesCat. No.: HY-135794RCAS No.: 32694-37-4Synonyms: 11-KDHT (Standard); 5α-Dihydro-11-keto testosterone (Standard)11-Ketodihydrotestosterone (Standard) is the analytical standard of 11-Ketodihydrotestosterone. This product is intended for research and analytical applications. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells.
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LG-120753
0 ImagesCat. No.: HY-183518CAS No.: 179894-84-9LG-120753 is an orally active nonsteroidal progesterone receptor (PR) antagonist, with an IC50 of 38 nM against hPR-B, a Ki of 19 nM against hPR-A, an IC50 of 227 nM against hAR, and IC50 values greater than 1000 nM against hGR, hER and hMR. LG-120753 blocks the action of progesterone, binds to and antagonizes hPR-A, and shows limited cross-reactivity with other steroid receptors. LG-120753 blocks blastocyst implantation, prevents the establishment of pregnancy, exhibits dose-dependent antiprogestogenic activity in vivo, and induces reversible antifertility effects.
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Trimegestone-13C,d3
0 ImagesCat. No.: HY-106827S1Synonyms: RU 27987-13C,d3Trimegestone-13C,d3 is 13C and deuterated labeled Trimegestone (HY-106827). Trimegestone (RU 27987) is an orally active 19-norpregnane progestin. Trimegestone binds to progesterone receptor (PR) with an IC50 value of 3.3 nM (rat PR). Trimegestone increases alkaline phosphatase activity (EC50=0.1 nM) but not luciferase activity. Trimegestone also shows a weak antiandrogenic activity (weak androgen receptor affinity). Trimegestone can be used in studies of contraception or menopausal syndromes.
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Varilutamide
0 ImagesCat. No.: HY-114246CAS No.: 1351185-54-0Synonyms: ONC1-13BVarilutamide (ONC1-13B) is an orally active androgen receptor (AR) inhibitor. Varilutamide shows a rat AR IC50 of 7.9 μM, inhibits DHT-stimulated PSA expression and prostate cancer cell proliferation, suppresses tumor growth and PSA expression and weakly induces lower CYP3A activity. Varilutamide can be used for the research of castration-resistant prostate cancer and prostate cancer.
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Trestolone acetate
0 ImagesCat. No.: HY-W744216CAS No.: 6157-87-5Trestolone acetate is an androgenic steroid. Trestolone acetate binds to Sugammadex sodium (HY-B0079), reducing the ability of Sugammadex sodium to reverse amino steroid neuromuscular blocking agents.
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Mebolazine
0 ImagesMebolazine binds to the androgen receptor and produce androgenic and anabolic activity.
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Alternariol-d2
0 ImagesCat. No.: HY-W653896CAS No.: 2469262-26-6Alternariol-d2 is deuterium labeled Alternariol. Alternariol is an orally ingested mycotoxin produced by Alternaria, capable of inhibiting the activity of topoisomerase I and II (topoisomerase I, topoisomerase II). Alternariol has weak estrogenic (Estrogen Receptor/ERR) and androgen/antiandrogen (Androgen Receptor) effects. Alternariol can induce apoptosis, trigger cell cycle arrest, suppress innate immune responses, and exhibit anti-tumor activity. Alternariol has genotoxic, mutagenic, and endocrine-disrupting effects.
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Triticonazole
0 ImagesCat. No.: HY-B2058CAS No.: 131983-72-7Triticonazole is an orally active triazole fungicide and androgen receptor antagonist. Triticonazole inhibits testosterone-induced androgen receptor activation and reduces basal testosterone secretion. Prenatal exposure to Triticonazole causes shortened anogenital distance in male rat fetuses and induces organ-specific histopathological changes in pigs. Triticonazole can be used for detoxification of seeds contaminated with fungal pathogens, but there is a risk of animal poisoning if the treated seeds are used as animal feed.
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Bromopropylate (Standard)
0 ImagesCat. No.: HY-B2044RCAS No.: 18181-80-1Bromopropylate (Standard) is the analytical standard of Bromopropylate. This product is intended for research and analytical applications. Bromopropylate is a pesticide with moderate anti-androgenic activities.
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Adrenosterone (Standard)
0 ImagesAdrenosterone (Standard) is the analytical standard of Adrenosterone. This product is intended for research and analytical applications. Adrenosterone ((+)-Adrenosterone) is a competitive hydroxysteroid (11-beta) dehydrogenase 1 (HSD11β1) inhibitor. Adrenosterone is a steroid hormone with weak androgenic effect. Adrenosterone is a dietary supplement that can decrease fat and increase muscle mass. Adrenosterone acts as a suppressor of metastatic progression of human cancer cells.
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Trisdecanoin (Standard)
0 ImagesSynonyms: Tricaprin (Standard); Glyceryl tridecanoate (Standard)Trisdecanoin (Standard) is the analytical standard of Trisdecanoin. This product is intended for research and analytical applications. Trisdecanoin (Tricaprin; Glyceryl tridecanoate) is an orally available precursor of decanoic acid (DA precursor) that can be hydrolyzed to decanoic acid. Trisdecanoin and its metabolite capric acid not only provide the body with a quick source of energy, but can also affect lipid metabolism. Trisdecanoin is a major component of medium chain triglycerides (MCT), which has preventive or inhibitory properties for abdominal aortic aneurysms (AAA), inhibition of cardiovascular disease, and anti-androgen (NSAA) and anti-hyperglycemic properties. Trisdecanoin can be used as an additive in food, medicine and cosmetics.
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(R)-Bicalutamide (Standard)
0 ImagesCat. No.: HY-108250RCAS No.: 113299-40-4(R)-Bicalutamide (Standard) is the analytical standard of (R)-Bicalutamide (HY-108250). This product is intended for research and analytical applications. (R)-Bicalutamide is the (R)-enantiomer of Bicalutamide (HY-14249). (R)-Bicalutamide is an androgen receptor (AR) antagonist, with antineoplastic activity. (R)-Bicalutamide is widely used for the research of prostate cancer.
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LGD-3303 (Standard)
0 ImagesCat. No.: HY-103576RCAS No.: 917891-35-1LGD-3303 (Standard) is the analytical standard of LGD-3303 (HY-103576). This product is intended for research and analytical applications. LGD-3303 is a selective androgen receptor modulator (SARM).
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4'-Methoxyflavonol (Standard)
0 ImagesCat. No.: HY-111803RCAS No.: 6889-78-74'-Methoxyflavonol (Standard) is the analytical standard of 4'-Methoxyflavonol (HY-111803). This product is intended for research and analytical applications. 4'-Methoxyflavonol is a flavonol. 4'-Methoxyflavonol reduces androgen receptor and increases SOD. 4'-Methoxyflavonol reduces plasma glucose, cholesterol, and triglycerides. 4'-Methoxyflavonol has anti-stress and antioxidant activities. 4'-Methoxyflavonol can be used in prostate cancer research.
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Clascoterone-d5-1
0 ImagesCat. No.: HY-13331S2Synonyms: Cortexolone 17 alpha-propionate-d5-1; Cortexolone 17α-propionate-d5-1; CB-03-01-d5-1Clascoterone-d5-1 (Cortexolone 17 alpha-propionate-d5-1) is deuterium labeled Clascoterone. Clascoterone (Cortexolone 17 alpha-propionate;Cortexolone 17α-propionate;CB-03-01) is a new topical and peripherally selective androgen antagonist.
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Topterone
0 ImagesCat. No.: HY-U00198CAS No.: 60607-35-4Synonyms: Win 17665Topterone is a topical antiandrogen.
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Carbazole derivative 1
0 ImagesCat. No.: HY-U00323CAS No.: 164914-28-7Synonyms: 2-Fluoro-7-[(3-pyridinyl)methyl]-9H-carbazoleCarbazole derivative 1 is a carbazole derivative which can be used to reduce androgen or oestrogen levels in mammals, including humans.
