Androgen Receptor Ligand

AR/BRD4 RIPTAC-1 (Compound II-5) is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 holds promise for use in prostate cancer research.

Chlormadinone acetate is a progestogen with potent progestogenic activity and antiandrogenic effects. Chlormadinone acetate acts on glucocorticoid receptor, progesterone receptor, androgen receptor, and GABA_A receptor. Chlormadinone acetate induces endometrial proliferation in estrogen-pretreated rabbits, inhibits testosterone-stimulated growth of the prostate and seminal vesicles in castrated rats, and reduces the thymus and adrenal weights in juvenile rats. Chlormadinone acetate is applicable to research related to diseases such as depression and reproductive metabolic disorders.

AR ligand-30 is a target protein ligand targeting AR, which can be used in studies related to PROTAC synthesis, such as serving as the target protein ligand for PROTAC Bavdegalutamide (HY-138641).

AR/BRD4 RIPTAC-1 (Compound II-5) TFA is an orally active Regulatory-inducible proximity-targeting chimera (RIPTAC). AR/BRD4 RIPTAC-1 TFA induces the formation of a stable ternary complex between the androgen receptor (AR) and BRD4, thereby blocking BRD4 function. AR/BRD4 RIPTAC-1 TFA inhibits the growth and proliferation of tumor cells. AR/BRD4 RIPTAC-1 TFA holds promise for use in prostate cancer research.

AR-V7 ligand-1 is a AR-V7 ligand and can be used for the synthesis of PROTACs, such as MTX-23 (HY-148771).

Farnesylacetone acts as a transcriptional regulator, RNA synthesis modulator, and male hormone. Farnesylacetone can be extracted from the androgenic glands of the green crab (Carcinus maenas). Farnesylacetone modulates transcriptional processes, inhibits uridine incorporation into all types of RNA and leucine incorporation into ovaries, while stimulating uridine incorporation into tRNA/poly (A)⁺ RNA and leucine incorporation into testes. It suppresses electron transport in mitochondrial Complex I and Complex II. Farnesylacetone inhibits vitellogenesis in crustacean ovaries and stimulates uridine incorporation in crustacean intestines. It functions as an androgen in crustaceans.

RU 56187 is an active compound.

AR ligand-46 is an androgen receptor (AR) ligand that can be used in studies related to PROTAC synthesis, such as serving as a target protein ligand for A031 (HY-148777).

AR ligand-45 is an androgen receptor (AR) ligand, which can be used for the synthesis of PROTACs, such as SJH1-62B (HY-162241).

AR ligand-33 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-8 (HY-170329) as the target protein ligand.

AR ligand-38 is the ligand for androgen receptor, that can be used for synthesis of PROTAC AR Degrader-9 (HY-170448).

CBP/p300-IN-25 is a CBP/p300 heterobifunctional conditional inhibitor. CBP/p300-IN-25 mediates conditional CBP/p300 inhibition through simultaneous binding to CBP/p300 and AR. CBP/p300-IN-25 is applicable to the research of prostate cancer.

AR/BET ligand-1 is a AR/BET ligand, which can be used for the synthesis of PROTACs, such as PROTAC AR/BET protein degrader-1 (HY-160262).

AR ligand-49 (Compound 4q) is a dual ligand for the adenosine A_2A receptor (A_2AAR) and the A₃ receptor (A₃AR). Its K_i values are 15 and 4.5 nM respectively. AR ligand-49 exhibits reverse agonistic activity at hA_2AAR and antagonistic activity at hA₃AR. AR ligand-49 can be used for the study of the design and development of adenosine receptor ligands.

Androgen receptor ligand 4 (Compound MDG486) is an androgen receptor ligand with an IC₅₀ of >100 µM. Androgen receptor ligand 4 can be used in the research of adolescent development.

SRC2-2 peptide is a a coactivator-derived mimic targeting androgen receptor (AR) ligand. SRC2-2 peptide is promising for research of prostate cancer.

AR ligand 42 is a androgen receptor ligand. AR ligand 42 can be used to synthesize androgen receptor PROTAC degrader ITRI-90 (HY-171808).

AR ligand-39, an androgen receptor (AR) ligand, is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). AR ligand-39 can be used for synthesis PROTAC AR Degrader-10 (HY-173372).

AR ligand-4 is an androgen receptor (AR) ligand, which can be used for the synthesis of PROTACs, such as ARD-1676 (HY-156111).

AR ligand-32 is a target protein ligand, used for the synthesis of PROTAC AR Degrader-7 (HY-160221).