SJH1-62B
SJH1-62B is a selective Androgen receptor PROTAC degrader. SJH1-62B induces ubiquitination and degradation of the androgen receptor. SJH1-62B can be used for the research of prostate cancer.
(Pink: Androgen Receptor ligand (HY-175906); Blue: SKP1 ligand (HY-175905); Black: linker).
For research use only. We do not sell to patients.
- Formula: C48H63ClN8O5
- Molecular Weight:867.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
SJH1-62B (0.001-10 μM; 24 h) potently degrades androgen receptor in LNCaP prostate cancer cells[1].
SJH1-62B (1 μM; 24 h) selectively degrades androgen receptor in LNCaP prostate cancer cells, with only 11 additional proteins showing significant (>50%) reduced levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP prostate cancer cells
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Concentration:0.001, 0.01, 0.1, 1, 5, 10 μM
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Incubation Time:24 h
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Result:Showed potent and robust degradation of androgen receptor (AR) across tested concentrations relative to other SKP1-based AR PROTACs.
Chemical Information
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Molecular Weight 867.52
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Formula C48H63ClN8O5
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SMILES
O=C(C1=NN=C(N2CCN(CCCCCCCNC(CCCOC3=CC=CC(CC4CCN(C(C=C)=O)CC4)=C3)=O)CC2)C=C1)NC5CCC(OC6=CC=C(C#N)C(Cl)=C6)CC5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SJH1-62B Related Classifications
HY-162241 Related Classifications
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