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Cat. No.: HY-162241

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SJH1-62B

SJH1-62B is a proteolysis targeting chimera (PROTAC) that can target the androgen receptor (AR).
(Pink: Androgen Receptor ligand (HY-175906); Blue: SKP1 ligand (HY-175905); Black: linker).

For research use only. We do not sell to patients.

Formula: C₄₈H₆₃ClN₈O₅
Molecular Weight:867.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (260 KB)

SJH1-62B Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

SJH1-62B is a proteolysis targeting chimera (PROTAC) that can target the androgen receptor (AR)^[1]. (Pink: Androgen Receptor ligand (HY-175906); Blue: SKP1 ligand (HY-175905); Black: linker).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 867.52
Formula C₄₈H₆₃ClN₈O₅
SMILES

O=C(C1=NN=C(N2CCN(CCCCCCCNC(CCCOC3=CC=CC(CC4CCN(C(C=C)=O)CC4)=C3)=O)CC2)C=C1)NC5CCC(OC6=CC=C(C#N)C(Cl)=C6)CC5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (260 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hong SH, et al. Exploiting the Cullin E3 Ligase Adaptor Protein SKP1 for Targeted Protein Degradation. ACS Chem Biol. 2024 Feb 16;19(2):442-450. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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