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製品番号: HY-173372

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PROTAC AR Degrader-10

PROTAC AR Degrader-10 is a potent cereblon (CRBN)-recruited androgen receptor (AR) PROTAC degrader. PROTAC AR Degrader-10 exhibits high AR degradation activity and can be applied to research related to prostate cancer.
(Pink: Androgen Receptor ligand (HY-173373); Blue: Cereblon ligand (HY-138793); Black: linker).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₄₁H₄₆ClN₇O₅S
分子量:784.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

PROTAC AR Degrader-10 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

PROTAC AR Degrader-10 is a potent cereblon (CRBN)-recruited androgen receptor (AR) PROTAC degrader. PROTAC AR Degrader-10 exhibits high AR degradation activity and can be applied to research related to prostate cancer^[1]. (Pink: Androgen Receptor ligand (HY-173373); Blue: Cereblon ligand (HY-138793); Black: linker).

IC₅₀ & Target

CRBN-DDB1

PROTACs アイソフォーム固有の製品をすべて表示 :

体外実験

PROTAC AR Degrader-10 (GT19) (0.1-500 nM; 24 h) potently degrades androgen receptor in LNCaP human prostate cancer cells, with superior activity compared to Bavdegalutamide (ARV-110) (HY-138641) at concentrations below 100 nM over 24 hours, and obvious degradation at 100 nM over 24 hours^[1].
PROTAC AR Degrader-10 binds to human cereblon with high affinity, as measured by an IC₅₀ of 0.15 µM in a cell-free HTRF binding assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

LNCaP human prostate cancer cells
Concentration:

0.1-500 nM
Incubation Time:

24 h
Result:

Induced high androgen receptor degradation at concentrations below 100 nM over 24 hours.
Caused obvious androgen receptor degradation at a concentration of 100 nM over 24 hours.

Related Protocols :

Research Protocol for Endocrine Diseases

化学情報

分子量 784.37
分子式 C₄₁H₄₆ClN₇O₅S
SMILES

ClC1=C(C#N)C=CC(O[C@H]2C(C)(C)[C@H](NC(C3=CC=C(N4CCN(CCCSC5=CC=C(C(N(C6C(NC(CC6)=O)=O)C7)=O)C7=C5)CC4)N=C3)=O)C2(C)C)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1].
Li Zhang, et al. Predicting PROTAC-targeted Degradation and Designing Androgen Receptor Degraders with AiPROTAC. bioRxiv 2025.02.26.640266.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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