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Cat. No.: HY-185786

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CBP/p300-IN-25

CBP/p300-IN-25 is a CBP/p300 heterobifunctional conditional inhibitor. CBP/p300-IN-25 mediates conditional CBP/p300 inhibition through simultaneous binding to CBP/p300 and AR. CBP/p300-IN-25 is applicable to the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 3105154-92-2
Formula: C₅₄H₆₅ClF₂N₁₂O₂
Molecular Weight:987.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CBP/p300-IN-25 Chemical Structure

CAS No.: 3105154-92-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

All Epigenetic Reader Domain Isoforms :

In Vitro

CBP/p300-IN-25 (Compound 137) potently induces the formation of the AR:CBP ternary complex in cell-free assays, with an EC₅₀ of less than 1 nM^[1].
CBP/p300-IN-25 potently inhibits the growth of VCaP cells, with an IC₅₀ ≤ 0.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3105154-92-2
Molecular Weight 987.62
Formula C₅₄H₆₅ClF₂N₁₂O₂
SMILES

CC(N1CC2=C(CC1)N(C3CCN(CC3)C[C@H]4CC[C@@H](CC4)OC5=CC=C(N6CCC7(CN(C8=CC(Cl)=C(C=C8)C#N)[C@H](C7)C)CC6)N=N5)N=C2N9C%10=CC(C(F)F)=C(C%11=CN(C)N=C%11)C=C%10CCC9)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Taavi Neklesa, et al. Cbp/p300 heterobifunctional conditional inhibitors. WO2025221930A1. WIPO (PCT). 2025-04-16.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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