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  2. Androgen Receptor
  3. Topterone

Topterone (Synonyms: Win 17665)

Cat. No.: HY-U00198
Handling Instructions

Topterone is a topical antiandrogen.

For research use only. We do not sell to patients.

Topterone Chemical Structure

Topterone Chemical Structure

CAS No. : 60607-35-4

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Description

Topterone is a topical antiandrogen.

IC50 & Target

Androgen[1]

In Vivo

Topterone, is administered parenterally or topically to rats, rabbits or hamsters to determine its endocrine profile. Systemic administration demonstrates that Topterone is both antiandrogenic and progestational. Topical application fails to elicit a systemic antiandrogenic response at 1 g/kg/day and only a minimal progestational response is seen at 32 mg/kg/day. No other endocrine activities are detected[1]. Topterone inhibits stimulation of flank organ development of castrated immature male hamsters by both testosterone and dihydrotestosterone, whereas Progesterone inhibits the stimulation by only testosterone. Topical application of Topterone, has been shown to cause a regression in the development of the flank organ[2].

Molecular Weight

330.50

Formula

C₂₂H₃₄O₂

CAS No.

60607-35-4

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TopteroneWin 17665Win17665Win-17665Androgen ReceptorInhibitorinhibitorinhibit

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