2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0317F
    Amlodipine hydrochloride
    		Antagonist
    Amlodipine hydrochloride is a biologically active drug used to lower blood pressure and prevent chest pain. Amlodipine hydrochloride has shown synergistic effects with antimicrobial drugs in in vitro studies, especially against carbene peptide-resistant Acinetobacter baumannii. Amlodipine hydrochloride can be used in combination with other antibiotics to enhance the inhibitory effect against resistant bacteria. The use of amlodipine hydrochloride helps reduce the dosage requirements of the drug, reduce toxic effects, and delay the emergence of drug resistance.
    Amlodipine hydrochloride
  • HY-B0768AR
    Lomerizine dihydrochloride (Standard)
    		Antagonist
    Lomerizine dihydrochloride (Standard) is the analytical standard of Lomerizine dihydrochloride. This product is intended for research and analytical applications. Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine dihydrochloride (Standard)
  • HY-B0768S
    Lomerizine-d4
    		Antagonist
    Lomerizine-d4 is the deuterium labeled Lomerizine (HY-B0768). Lomerizine is an antagonist of L- and T-type voltagegated calcium channels.
    Lomerizine-d<sub>4</sub>
  • HY-106766
    DHP-218
    		Antagonist
    DHP-218 is a vasodilatory calcium antagonist with pronounced and long-lasting antihypertensive effects .
    DHP-218
  • HY-B0317R
    Amlodipine (Standard)
    		Antagonist
    Amlodipine (Standard) is the analytical standard of Amlodipine. This product is intended for research and analytical applications. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.
    Amlodipine (Standard)
  • HY-106682
    Falipamil
    		Antagonist
    Falipamil (AQ-A 39), a calcium channel blocker, is a bradycardic agent. The bradycardic effect results from a reduction in the diastolic depolarization rate and a prolongation of the action potential duration.
    Falipamil
  • HY-U00212R
    Aranidipine (Standard)
    		Antagonist
    Aranidipine (Standard) is the analytical standard of Aranidipine. This product is intended for research and analytical applications. Aranidipine (MPC1304) is a Ca2+ channel antagonist with potent and long-lasting antihypertensive effects.
    Aranidipine (Standard)
  • HY-17436R
    Clevidipine (Standard)
    		Antagonist
    Clevidipine (Standard) is the analytical standard of Clevidipine. This product is intended for research and analytical applications. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).
    Clevidipine (Standard)
  • HY-156889
    Cav 3.1 blocker 1
    		Antagonist
    Cav 3.1 blocker 1 (compound 12) is a T-type calcium channel blocker with an IC50value of 160 nM for Cav3.1. Cav 3.1 blocker 1 weakly inhibits Cav 3.2 (IC50 of 5000 nM), and shows no inhibition on Cav 3.3 and Cav 1.2 (IC50 of >10000 nM).
    Cav 3.1 blocker 1
  • HY-108974R
    Drotaverine hydrochloride (Standard)
    		Antagonist
    Drotaverine (hydrochloride) (Standard) is the analytical standard of Drotaverine (hydrochloride). This product is intended for research and analytical applications. Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, blocks the degradation of 3',5'-cyclic adenosine monophosphate. Drotaverine (hydrochloride) exhibits in vivo antispasmodic efficacy without anticholinergic effects.
    Drotaverine hydrochloride (Standard)
  • HY-10341D
    Fasudil mesylate
    		Antagonist
    Fasudil (HA-1077; AT877) mesylate is a nonspecific and orally active RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil mesylate is also a potent Ca2+ channel antagonist and vasodilator.
    Fasudil mesylate
  • HY-19083
    SIM-6080
    		Antagonist
    SIM-6080 is a calcium antagonist and inhibits the proliferation of rat aortic myocytes and reduces aortic atherosclerosis in rabbits.
    SIM-6080
  • HY-10388R
    TTA-Q6 (Standard)
    		Antagonist
    TTA-Q6 (Standard) is the analytical standard of TTA-Q6 (HY-10388). This product is intended for research and analytical applications. TTA-Q6 is a selective T-type Ca2+ channel antagonist, which can be used in the research of neurological disease.
    TTA-Q6 (Standard)
  • HY-121019
    Flordipine
    		Antagonist
    Floripine is an orally active calcium antagonist with anti hypertensive activity.
    Flordipine
  • HY-118492
    Riodipine
    		Antagonist
    Riodipine (PP-1466) is a vasodilator. Riodipine can be used for the research of antihypertensive.
    Riodipine
  • HY-106239
    Fostedil
    		Antagonist
    Fostedil (KB 944) is a calcium antagonist that can be used in the research of heart diseases such as angina pectoris.
    Fostedil
  • HY-B0317S
    Amlodipine-1,1,2,2-d4 maleate
    		Antagonist 98.04%
    Amlodipine-1,1,2,2-d4 (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer.
    Amlodipine-1,1,2,2-d<sub>4</sub> maleate
  • HY-103315R
    Bepridil hydrochloride (Standard)
    		Antagonist
    Bepridil hydrochloride (Standard) is the analytical standard of Bepridil hydrochloride. This product is intended for research and analytical applications. Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
    Bepridil hydrochloride (Standard)
  • HY-107186
    EO-122
    		Antagonist
    EO-122 is a potent antagonist of calcium channel and sodium channel potentially for the research of arrhythmia.
    EO-122
  • HY-14656S3
    Diltiazem-d5 hydrochloride
    		Antagonist
    Diltiazem-d5 (CRD-401-d5) hydrochloride is deuterium-labeled Diltiazem (hydrochloride) (HY-14656).
    Diltiazem-d<sub>5</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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