Fungal
An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.
Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.
All Product Categories
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Fungal Related Products (2733)
Related Products (2733)
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Antibodies (1)
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Related Compound Screening Libraries (1)
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Zaragozic acid A trisodium
0 ImagesCat. No.: HY-116290ACAS No.: 144541-82-2Synonyms: Squalestatin S1 trisodiumZaragozic acid A trisodium is a fungal metabolite that acts as a reversible competitive inhibitor of squalene synthase.
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Bis(methylthio)gliotoxin
0 ImagesCat. No.: HY-N9710CAS No.: 74149-38-5Synonyms: Bisdethiobis(methylthio)gliotoxin; FR 49175; DimethylgliotoxinBis(methylthio)gliotoxin is a more stable and reliable marker for invasive aspergillosis than gliotoxin and suitable for use in diagnosis.
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Amphotericin X1
0 ImagesCat. No.: HY-136153CAS No.: 136135-57-4Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively.
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5CF2PB
0 Images5CF2PB is an antibacterial and antifungal agent. 5CF2PB targets 5O4L. 5CF2PB exhibits potent antibacterial and antifungal activities, particularly against Pseudomonas aeruginosa and Aspergillusniger.
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Hypocrellin B (Standard)
0 ImagesCat. No.: HY-N1453RCAS No.: 123940-54-5Hypocrellin B (Standard) is the analytical standard of Hypocrellin B. This product is intended for research and analytical applications. Hypocrellin B, a pigment isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, is an apoptosis inducer. Hypocrellin B can be used as a photosensitizer for photodynamic therapy of cancer. Hypocrellin B also has antimicrobial and antileishmanial activities[1][2][3].
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Meridinol
0 ImagesCat. No.: HY-N3296CAS No.: 120051-54-9Synonyms: (-)-MeridinolMeridinol ((-)-Meridinol) shows antimicrobial activity against a wide range of gram-positive and gram-negative bacteria and fungi.
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Chitin synthase inhibitor 3
0 ImagesCat. No.: HY-150584CAS No.: 2416338-26-4Chitin synthase inhibitor 3 (compound 2d) is a potent chitin synthase inhibitor with an IC50 value of 0.16 mM, and MIC of 1 µg/mL against candida albicans. Antifungal activity.
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Chrodrimanin H
0 ImagesCat. No.: HY-182490CAS No.: 1446801-59-7Chrodrimanin H (Compound 13) is a sesquiterpenoid compound. Chrodrimanin H is isolated from the fungus Talaromyces primulinus H21. Chrodrimanin H blocks lipopolysaccharide-induced NO production in immune cells with an IC50 of 24.71 μM.
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Antifungal agent 73
0 ImagesCat. No.: HY-155279CAS No.: 2923519-78-0Antifungal agent 73 (compound A32) is an antifungal agent for azole-resistant candidiasis. Antifungal agent 73 disrupts the fungal cell wall and cell membrane. Antifungal agent 73 shows potent in vivo antifungal activity against pathogenic fungi and fluconazole-resistant strains.
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Antioxidant/anticancer agent 1
0 ImagesCat. No.: HY-161071CAS No.: 1449470-38-5Antioxidant/anticancer agent 1 (compound 5) is a pyrimidine-derivatized Schiff base based on pyrimidine hydroxy-1-naphthaldehyde and has antibacterial, antioxidant, antifungal, and anticancer properties. Antioxidant/anticancer agent 1.
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CYP51-IN-20
0 ImagesCat. No.: HY-159585CYP51-IN-20 (compound 5b) is an inhibitor of CYP51 and has antifungal activity. CYP51-IN-20 has a significant inhibitory effect on Candida albicans ATCC 10231, downregulates ERG11 (Cyp51) gene expression, and significantly reduces the yeast-to-hyphae morphological transition. CYP51-IN-20 can synergize with Voriconazole (HY-76200) to occupy the entire CYP51 binding site and exert a synergistic inhibitory effect in the Glechoma moth model.
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Agar, microbiology tested, for cell culture (granular)
0 ImagesCat. No.: HY-W134423ACAS No.: 9002-18-0Agar, microbiology tested, for cell culture (granular) is a hydrocolloid with gelling ability. Agar, microbiology tested, for cell culture (granular) can be used to prepare microbial culture media (for bacteria, yeasts and molds).
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Elubiol
0 ImagesSynonyms: Dichlorophenyl imidazoldioxolanElubiol (Dichlorophenyl imidazoldioxolan) has moderate sebum-inhibiting activity and can be used in the treatment of oily skin or dandruff.
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Galanolactone
0 ImagesCat. No.: HY-N3916CAS No.: 115753-79-2Synonyms: (+)-GalanolactoneGalanolactone is a natural product that can be isolated from the seeds of Alpinia galanga. Galanolactone shows antifungal activitie. Galanolactone shows cytotoxicity against KB cells with an EC50 of 38.5 µg/ml.
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Epothilone B (Standard)
0 ImagesSynonyms: EPO 906 (Standard); Patupilone (Standard)Epothilone B (Standard) is the analytical standard of Epothilone B. This product is intended for research and analytical applications. Epothilone B is a microtubule stabilizer with a Ki of 0.71μM. It acts by binding to the αβ-tubulin heterodimer subunit which causes decreasing of αβ-tubulin dissociation.
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Malolactomycin C
0 ImagesCat. No.: HY-N13154CAS No.: 189759-03-3Malolactomycin C (compound 1) is a macrolide antifungal antibiotic isolated from Streptomyces strain KP-3144. Malolactomycin C is an effective inhibitor of Botrytis cinerea and thus controls a variety of plant diseases including gray mold.
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Antifungal agent 51
0 ImagesCat. No.: HY-149822CAS No.: 2896209-47-3Antifungal agent 51 (Compound 5c) has potent antifungal activity, especially against Candida albicans FDC 151 , Candida parapsilosis ATCC 22019 and Candida tropicalis FDC 138, with the MIC value is less than 0.063 μg/mL, and it has low toxicity to cells and no carcinogenicity.
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Partricin
0 ImagesCat. No.: HY-N21835CAS No.: 11096-49-4Partricin is an aromatic heptaene macrolide antibiotic complex consisting of partricin A and B, an antifungal agent found in Streptomyces aureofaciens. Partricin exhibits antifungal activity. Partricin has poor selective toxicity in the pathogen/host system. Partricin can be used for the research of fungal infections.
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Sertaconazole nitrate (Standard)
0 ImagesSynonyms: FI7056 (Standard)Sertaconazole (nitrate) (Standard) is the analytical standard of Sertaconazole (nitrate). This product is intended for research and analytical applications. Sertaconazole nitrate (FI7056) is a broad-spectrum topical antifungal agent, exhibits anti-inflammatory activity via activation of a p38-COX-2-PGE2 pathway. Sertaconazole nitrate is also a microtubule inhibitor, shows antiproliferative effect, induces apoptosis and autophagy, and can also inhibit the migration of cells.
