Free Fatty Acid Receptor
FFAR
Free fatty acid receptors (FFARs) are G protein-coupled receptors (GPCRs) activated by free fatty acids (FFAs). The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. FFARs are categorized according to the chain length of FFA ligands that activate each FFAR; FFA2 and FFA3 are activated by short chain FFAs, mainly acetate, butyrate, and propionate. GPR84 is activated by medium-chain FFAs, whereas FFA1 and GPR120 are activated by medium- or long-chain FFAs. Thus, each FFAR can act as an FFA sensor with selectivity for a particular FFA carbon chain length derived from food or food derived metabolites. FFARs have been reported to have physiological functions such as facilitation of insulin and incretin hormone secretion, adipocyte differentiation, anti-inflammatory effects, neuronal responses, and taste preferences. These physiological functions of FFARs could be considered to regulate energy and immune homeostasis. Therefore, FFARs have been targeted in therapeutic strategies for the treatment of metabolic disorders including type 2 diabetes and metabolic syndrome.
Free Fatty Acid Receptor Isoform Specific Products
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Free Fatty Acid Receptor Inhibitors
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Free Fatty Acid Receptor Agonists
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Free Fatty Acid Receptor Antagonists
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Free Fatty Acid Receptor Activators
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Free Fatty Acid Receptor Ligand
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Free Fatty Acid Receptor Related Products (131)
Related Products (131)
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Antibodies (4)
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Free Fatty Acid Receptor Isoform Comparison
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LY2922083
0 ImagesCat. No.: HY-117978CAS No.: 1309435-78-6LY2922083 and related compounds LY2881835 and LY2922470 are spiperidine and tetrahydroquinolinic acid derivatives that are potent GPR40 agonists. LY2922083 activates GPR40 in response to elevated blood glucose and has the potential to be a glucose-lowering agent.
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GPR40 agonist 4 (Standard)
0 ImagesCat. No.: HY-103083RCAS No.: 2102196-57-4GPR40 agonist 4 (Standard) is the analytical standard of GPR40 agonist 4 (HY-103083). This product is intended for research and analytical applications. GPR40 agonist 4 is a potent free fatty acid receptor 1 (FFA1/ GPR40) agonist with a pEC50 of 7.54.
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GPR40/FFAR1 modulator 1 (Standard)
0 ImagesCat. No.: HY-111763RCAS No.: 874755-26-7GPR40/FFAR1 modulator 1 (Standard) is the analytical standard of GPR40/FFAR1 modulator 1 (HY-111763). This product is intended for research and analytical applications. GPR40/FFAR1 modulator 1 is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1).
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Fasiglifam (Standard)
0 ImagesCat. No.: HY-10480RCAS No.: 1000413-72-8Synonyms: TAK-875 (Standard)Fasiglifam (Standard) is the analytical standard of Fasiglifam (HY-10480). This product is intended for research and analytical applications. Fasiglifam (TAK-875) is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 72 nM.
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GPR120 Agonist 3 (Standard)
0 ImagesGPR120 Agonist 3 (Standard) is the analytical standard of GPR120 Agonist 3 (HY-101492). This product is intended for research and analytical applications. GPR120 Agonist 3 is a selective Gpr120 agonist with a logEC50 of 7.62.
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Fezagepras sodium (Standard)
0 ImagesSynonyms: Setogepram sodium (Standard); PBI-4050 sodium (Standard)Fezagepras (sodium) (Standard) is the analytical standard of Fezagepras (sodium). This product is intended for research and analytical applications. Fezagepras (Setogepram) sodium acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras sodium decreases renal, liver and pancreatic fibrosis. Fezagepras sodium exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
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(±)-Pinocembrin (Standard)
0 ImagesSynonyms: (±)-5,7-Dihydroxyflavanone (Standard); NSC 43318 (Standard)(±)-Pinocembrin (Standard) is the analytical standard of (±)-Pinocembrin. This product is intended for research and analytical applications. (±)-Pinocembrin ((±)-5,7-Dihydroxyflavanone) is a GPR120 ligand able to promote wound healing in HaCaT cell line.
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DC260126 (Standard)
0 ImagesCat. No.: HY-101906RCAS No.: 346692-04-4DC260126 (Standard) is the analytical standard of DC260126 (HY-101906). This product is intended for research and analytical applications. DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.
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Fezagepras (Standard)
0 ImagesCat. No.: HY-100775ARCAS No.: 1002101-19-0Synonyms: Setogepram (Standard); PBI-4050 (Standard)Fezagepras (Standard) is the analytical standard of Fezagepras. This product is intended for research and analytical applications. Fezagepras (Setogepram) acts as an orally active agonist for GPR40 and as an antagonist or inverse agonist for GPR84. Fezagepras decreases renal, liver and pancreatic fibrosis. Fezagepras exerts anti-fibrotic, anti-inflammatory and anti-proliferative actions.
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TUG-1609
0 ImagesCat. No.: HY-185287CAS No.: 2101952-37-6TUG-1609 is a fluorescent tracer targeting free fatty acid receptor 2 (FFA2/GPR43) with a Kd value of 65.1 nM.
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GPR40 Agonist 2
0 ImagesCat. No.: HY-U00395CAS No.: 1147729-48-3GPR40 Agonist 2 is a GPR40 agonist that can be used in the research of diabetes, extracted from patent WO2009054479A1.
