Free Fatty Acid Receptor
FFAR
Free fatty acid receptors (FFARs) are G protein-coupled receptors (GPCRs) activated by free fatty acids (FFAs). The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. FFARs are categorized according to the chain length of FFA ligands that activate each FFAR; FFA2 and FFA3 are activated by short chain FFAs, mainly acetate, butyrate, and propionate. GPR84 is activated by medium-chain FFAs, whereas FFA1 and GPR120 are activated by medium- or long-chain FFAs. Thus, each FFAR can act as an FFA sensor with selectivity for a particular FFA carbon chain length derived from food or food derived metabolites. FFARs have been reported to have physiological functions such as facilitation of insulin and incretin hormone secretion, adipocyte differentiation, anti-inflammatory effects, neuronal responses, and taste preferences. These physiological functions of FFARs could be considered to regulate energy and immune homeostasis. Therefore, FFARs have been targeted in therapeutic strategies for the treatment of metabolic disorders including type 2 diabetes and metabolic syndrome.
Free Fatty Acid Receptor Isoform Specific Products
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Free Fatty Acid Receptor Inhibitors
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Free Fatty Acid Receptor Agonists
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Free Fatty Acid Receptor Antagonists
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Free Fatty Acid Receptor Activators
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Free Fatty Acid Receptor Modulators
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Free Fatty Acid Receptor Ligand
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Free Fatty Acid Receptor Related Products (131)
Related Products (131)
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Antibodies (4)
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Free Fatty Acid Receptor Isoform Comparison
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TUG-2304
0 ImagesTUG-2304 is a highly selective free fatty acid receptor 2 (FFA2, GPR43) antagonist that completely suppresses propionate-induced neutrophil migration and respiratory burst. TUG-2304 is applicable to research related to metabolic and inflammatory diseases.
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K-757
0 ImagesCat. No.: HY-175420CAS No.: 2696409-13-7K-757 is an orally active, gut-targeted GPR40 agonist with EC50 values of 2.1 nM, 5.6 nM, 4.2 nM and 166 nM in humans, mice, rats and dogs, respectively. K-757 activates nutrient receptors co-expressed on pancreatic β cells and intestinal enteroendocrine cells. K-757 mediates and induces the secretion of satiety hormones GLP-1 and PYY in multiple in vitro and in vivo models. When used in combination with GPR119 agonist K-833, K-757 acts as a potentiator to elevate circulating levels of satiety hormones. K-757 can be used in the research of type 2 diabetes, weight loss and other related metabolic disorders.
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MK-2305
0 ImagesCat. No.: HY-153667CAS No.: 2101206-49-7MK-2305 is an orally active GPR40 partial agonist with an EC50 of 6 nM in rats. MK-2305 mediates glucose-stimulated insulin secretion and inhibits endogenous glucose production by reducing gluconeogenesis from tricarboxylic acid (TCA) cycle substrates. MK-2305 increases plasma insulin levels under hyperglycemic and glucose-stimulated conditions, reduces fasting blood glucose, and improves glucose homeostasis. MK-2305 can be used in studies related to type 2 diabetes.
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GPR120 Agonist 4
0 ImagesCat. No.: HY-160628CAS No.: 1628641-89-3GPR120 Agonist 4 (example 1) is a GPR120 agonist，with the EC50 values of 1 μM and 0.35 μM for β-arrestin A and Calcium A. GPR120 Agonist 4 can be used for the research of type II diabetes mellitus.
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AS2575959 sodium
0 ImagesCat. No.: HY-123871CAS No.: 1616871-34-1AS2575959 (sodium) is an agonist of GPR40. AS2575959 (sodium) can enhance glucose metabolism and has synergic effect with Sitagliptin (HY-13749) on insulin as well as incretin secretion. AS2575959 (sodium) can be studied in research on type 2 diabetes.
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GPR40 agonist 5
0 ImagesCat. No.: HY-147678CAS No.: 2443384-60-7GPR40 agonist 5 (compound I-14) is an orally active and potent GPR40 (G protein coupled receptor 40) agonist, with an EC50 of 47 nM. GPR40 agonist 5 decreases the levels of blood glucose and improves the glucose tolerance. GPR40 agonist 5 has sufficient effectiveness for the control of hyperglycemia state in type 2 diabetic mice. GPR40 agonist 5 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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AM-6226
0 ImagesCat. No.: HY-120493ACAS No.: 1449742-87-3AM-6226 is a potent and orally active G protein coupled receptor 40 (GPR40) full agonist with an EC50 of 0.12 μM. AM-6226 can activate the GPR40 receptors on pancreatic β cells and enteroendocrine L cells, promote insulin secretion in a glucose-dependent manner and also increase the release of incretin hormones (GLP-1, GIP), thereby avoiding the risk of hypoglycemia. AM-6226 can be used for the research of metabolic disease, such as diabetes.
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GPR40 agonist 7
0 ImagesCat. No.: HY-162136CAS No.: 1821647-46-4
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Xelaglifam
0 ImagesCat. No.: HY-147420CAS No.: 2230597-99-4Synonyms: IDG-16177Xelaglifam is a potent GPR40 agonist. Antihyperglycaemic activity. Xelaglifam is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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HDAC6-IN-61
0 ImagesCat. No.: HY-176733HDAC6-IN-61 (Compound 4e) is a HDAC6 inhibitor (IC50: 73 nM) with selectivity over other HDAC isoforms. HDAC6-IN-61 is also a GPR40 activator. HDAC6-IN-61 increases acetylated tubulin and ERK phosphorylation levels. HDAC6-IN-61 can be used for research of neuroinflammation such as Alzheimer's disease.
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GPR41 modulator 2
0 ImagesCat. No.: HY-163531CAS No.: 3050769-11-1GPR41 modulator 2 (Compound 10bx) exhibits agonistic activity for G protein-coupled receptor (GPR41).
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MK-8666 tromethamine
0 ImagesCat. No.: HY-141653CAS No.: 2056254-98-7MK-8666 (tromethamine) is a GPR40 agonist. MK-8666 (tromethamine) can be used in the research of type II diabetes.
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(rel)-AM-6226
0 ImagesCat. No.: HY-120493CAS No.: 1142222-28-3(rel)-AM-6226 is the relative stereoisomer of AM-6226 (HY-120493A). AM-6226 is a potent, orally active full agonist of G protein-coupled receptor 40 (GPR40) with an EC50 value of 0.12 μM. AM-6226 activates GPR40 receptors on pancreatic β-cells and enteroendocrine L-cells, promotes insulin secretion in a glucose-dependent manner, and increases the release of incretin hormones (GLP-1, GIP), thus avoiding the risk of hypoglycemia. AM-6226 can be used in the research of metabolic diseases such as diabetes.
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FFAR1/FFAR4 agonist-1
0 ImagesCat. No.: HY-164870CAS No.: 2839486-16-5
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Phytosphingosine-d7
0 ImagesCat. No.: HY-W011303SSynonyms: 4-Hydroxysphinganine-d7Phytosphingosine-d7 (4-Hydroxysphinganine-d7) is deuterium labeled Phytosphingosine. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes.
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GPR40 agonist 9
0 ImagesCat. No.: HY-160631CAS No.: 1877252-91-9GPR40 agonist 9 (Example 21) is a G protein-coupled receptor 40 (GPR40) agonist with an EC50 of 0.21 nM. GPR40 agonist 9 is applicable to research related to type 2 diabetes, obesity, and other associated conditions.
