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Cat. No.: HY-186246

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TUG-2304

TUG-2304 is a highly selective free fatty acid receptor 2 (FFA2, GPR43) antagonist that completely suppresses propionate-induced neutrophil migration and respiratory burst. TUG-2304 is applicable to research related to metabolic and inflammatory diseases.

For research use only. We do not sell to patients.

CAS No.: 3034674-48-8
Formula: C₂₀H₂₀F₃N₅O₂
Molecular Weight:419.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TUG-2304 Chemical Structure

CAS No.: 3034674-48-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

GPR43

All Free Fatty Acid Receptor Isoforms :

In Vitro

TUG-2304 (compound 16l) (1 nM-10 μM) completely inhibits propionate-induced migration of human neutrophils over the concentration range of 1 nM to 10 μM^[1].
TUG-2304 (100 pM-10 μM) completely inhibits propionate-induced respiratory burst in human neutrophils, with a pIC₅₀ of 8.24 nM, and its activity is specific to FFA2-mediated activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_max	C_max	AUC_0-∞	Bioavailability	T_1/2	V_d	CL_total
Mice^[1]	5 mg/kg	i.v.	/	/	441000 min·ng/mL	/	24 min	400 mL/kg	11 mL/min/kg
Mice^[1]	10 mg/kg	p.o.	30 min	6240 ng/mL	389000 min·ng/mL	44 %	/	/	/

In Vivo

TUG-2304 (compound 16l) (5-10 mg/kg; i.v., p.o.; single dose) exhibits favorable pharmacokinetic properties in male BALB/cAnC mice, with an oral bioavailability of 44%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3034674-48-8
Molecular Weight 419.40
Formula C₂₀H₂₀F₃N₅O₂
SMILES

FC(F)(F)C(C=C1)=CC=C1C[C@H](NC(CC2=CC(OC)=CC=C2)=O)CC3=NN=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Valentini A, et al. Discovery of Potent Tetrazole Free Fatty Acid Receptor 2 Antagonists. Journal of medicinal chemistry. 2023 May 11;66(9):6105-6121. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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TUG-2304

All Free Fatty Acid Receptor Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TUG-2304 Related Classifications

HY-186246 Related Classifications