2101206-49-7
Chemical Structure
MK-2305
- CAS No.: 2101206-49-7
- Formula:C19H13ClF3NO4S
- Molecular Weight:443.82
IUPAC Name: 5-(7-(2-chloro-4-(trifluoromethyl)phenoxy)chroman-4-yl)thiazolidine-2,4-dione
InChIKey: BNLPZWKDLMCCAZ-UHFFFAOYSA-N
SMILES: O=C1SC(C(=O)N1)C2C3=CC=C(OC4=CC=C(C=C4Cl)C(F)(F)F)C=C3OCC2
Biological Activity: MK-2305 is an orally active GPR40 partial agonist with an EC50 of 6 nM in rats. MK-2305 mediates glucose-stimulated insulin secretion and inhibits endogenous glucose production by reducing gluconeogenesis from tricarboxylic acid (TCA) cycle substrates. MK-2305 increases plasma insulin levels under hyperglycemic and glucose-stimulated conditions, reduces fasting blood glucose, and improves glucose homeostasis. MK-2305 can be used in studies related to type 2 diabetes[1][2].
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MK-2305 | MK-2305 is an orally active GPR40 partial agonist with an EC50 of 6 nM in rats. MK-2305 mediates glucose-stimulated insulin secretion and inhibits endogenous glucose production by reducing gluconeogenesis from tricarboxylic acid (TCA) cycle substrates. MK-2305 increases plasma insulin levels under hyperglycemic and glucose-stimulated conditions, reduces fasting blood glucose, and improves glucose homeostasis. MK-2305 can be used in studies related to type 2 diabetes. | |||||||||||||||||||||
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References
- [1]. Miller C, et al. GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production. PLoS One. 2017;12(5):e0176182. Published 2017 May 23. [Content Brief]
- [2]. Zhong YL, et al. Highly Enantioselective Rhodium-Catalyzed Transfer Hydrogenation of Tetrasubstituted Olefins: Application toward the Synthesis of GPR40 Agonist MK-2305. Org Lett. 2022;24(17):3254-3258. [Content Brief]
