Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2433)
Related Products (2433)
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Adenosine 2'-PEG-Biotin
0 ImagesAdenosine 2'-PEG-Biotin is a biochemical reagent derived from adenosine. Adenosine 2'-PEG-Biotin regulates cell signaling pathways by mimicking the effects of endogenous adenosine and binding to its receptors. Adenosine 2'-PEG-Biotin can be used in the research of bioprobes, biosensors and diagnostic reagents.
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Ganciclovir-d5
0 ImagesSynonyms: BW 759-d5; 2'-Nor-2'-deoxyguanosine-d5Ganciclovir-d5 is the deuterium labeled Ganciclovir. Ganciclovir (BW 759), a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1).
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Dideoxycytidinene
0 ImagesSynonyms: 2′,3′-Didehydro-2′,3′-dideoxycytidineDideoxycytidinene (2′,3′-Didehydro-2′,3′-dideoxycytidine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine
0 Images(2S,3R,5S)-7-Deaza-2'-deoxy-7-iodoadenosine is the isomer of 7-Deaza-2'-deoxy-7-iodoadenosine (HY-W048490), and can be used as an experimental control. 7-Deaza-2'-deoxy-7-iodoadenosine is a modified oligonucleotide containing 7-Deazaadenine.
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Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade
0 ImagesCat. No.: HY-W013715BCAS No.: 27821-54-1Synonyms: dTTP trisodium,100 mM Solution,PCR GradeDeoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade (dTTP trisodium,100 mM Solution,PCR Grade) is a deoxyribonucleoside triphosphate and a thymidine analog, which serves as a direct precursor for DNA synthesis. Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade can be used for DNA amplification in the DNA polymerase chain reaction (PCR). Deoxythymidine-5'-triphosphate trisodium,100 mM Solution,PCR Grade is also applicable to research related to diseases such as leukemia.
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3'-NH2-ddA
0 ImagesSynonyms: 3'-Amino-2',3'-dideoxyadenosine3'-NH2-ddA (3'-Amino-2',3'-dideoxyadenosine) is a monomeric raw material that can be used for nucleic acid synthesis.
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DMT-dI
0 ImagesSynonyms: 5'-O-DMT-dI; 2'-Deoxy-5'-O-DMT-inosineDMT-dI (5'-O-DMT-dI) is a deoxyribonucleoside containing a hypoxanthine base. DMT-dI can be used to prepare convertible nucleoside derivatives to prepare modified oligonucleotides complementary to target genes for gene editing. DMT-dI can be used to study various conditions, disorders or diseases modified by adenosine.
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Ribavirin 5'-monophosphate dilithium
0 ImagesCat. No.: HY-129972CAS No.: 66983-94-6Synonyms: RMP dilithiumRibavirin 5'-monophosphate dilithium is an active form of ribavirin that inhibits IMP dehydrogenase, and ribavirin itself is a broad-spectrum antiviral agent.
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N-Benzoylcytidine
0 ImagesN-Benzoylcytidine is a modified cytidine analogue that can be phosphorylated by uracil-cytidine kinase (UCK1 and UCK2). N-Benzoylcytidine can be used to synthesize 2-OH protective groups for solid-phase RNA synthesis, as well as synthetic oligonucleotides for UV induction and targeted gene silencing in zebrafish embryos.
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2’-Azido-2’-deoxycytidine
0 Images2’-Azido-2’-deoxycytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 2’-Azido-2’-deoxycytidine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. 2’-Azido-2’-deoxycytidine is an azidonucleoside,and it should be phosphorylated twice to become an inhibitor of the nucleotide reductase.
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6-Methylpurine riboside
0 ImagesSynonyms: 6-MPR6-Methylpurine riboside (6-MPR) is an antibiotic extracted from the culture medium of the basidiomycete fungi Collybia dryophilia and Collybia maculata. 6-Methylpurine riboside possesses antifungal, antiviral, and antitumor activities.
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Stavudine (Standard)
0 ImagesStavudine (Standard) is the analytical standard of Stavudine. This product is intended for research and analytical applications. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA). Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis.
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2'-O-POM-rA(Bz)
0 Images2'-O-POM-rA(Bz) is a monomeric raw material that can be used for nucleic acid synthesis.
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3’-O-(2-Methoxyethyl)guanosine
0 Images3’-O-(2-Methoxyethyl)guanosine is a guanosine analogue. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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Pseudouridine (Standard)
0 ImagesPseudouridine (Standard) is the analytical standard of Pseudouridine. This product is intended for research and analytical applications. Pseudouridine is an isomer of the nucleoside uridine, and the most abundant modified nucleoside in non-coding RNAs. Pseudouridine in rRNA and tRNA can fine-tune and stabilize the regional structure and help maintain their functions in mRNA decoding, ribosome assembly, processing and translation[4].
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iBu-dG
0 ImagesSynonyms: N2-Isobutyryl-2'-deoxyguanosineiBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.
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N4-Benzoyl-2'-fluoro-2'-deoxycytidine
0 ImagesCat. No.: HY-W115023CAS No.: 146954-76-9N4-Benzoyl-2'-fluoro-2'-deoxycytidine is a monomeric raw material that can be used for nucleic acid synthesis.
