iBu-dG (Synonyms: N2-Isobutyryl-2'-deoxyguanosine)

Cat. No.: HY-W016011 Purity: 98.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides.

For research use only. We do not sell to patients.

iBu-dG Chemical Structure

CAS No. : 68892-42-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	In-stock	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides^[1].

In Vitro

iBu-dG (N2-Isobutyryl-2'-deoxyguanosine) is a nucleoside analog that can be used to synthesize oligoribonucleotides^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

337.34

Formula

C₁₄H₁₉N₅O₅

CAS No.

68892-42-2

Appearance

Solid

Color

White to off-white

SMILES

OC[C@H]([C@@H](O)C1)O[C@H]1N2C(N=C(NC(C(C)C)=O)N=C3O)=C3N=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (296.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.9644 mL	14.8218 mL	29.6437 mL
5 mM	0.5929 mL	2.9644 mL	5.9287 mL
10 mM	0.2964 mL	1.4822 mL	2.9644 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.0%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (249 KB) HNMR (122 KB)

Handling Instructions (2659 KB)

References

[1]. Schulhof JC, et al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups. Nucleic Acids Res. 1987 Jan 26;15(2):397-416. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9644 mL	14.8218 mL	29.6437 mL	74.1092 mL
	5 mM	0.5929 mL	2.9644 mL	5.9287 mL	14.8218 mL
	10 mM	0.2964 mL	1.4822 mL	2.9644 mL	7.4109 mL
	15 mM	0.1976 mL	0.9881 mL	1.9762 mL	4.9406 mL
	20 mM	0.1482 mL	0.7411 mL	1.4822 mL	3.7055 mL
	25 mM	0.1186 mL	0.5929 mL	1.1857 mL	2.9644 mL
	30 mM	0.0988 mL	0.4941 mL	0.9881 mL	2.4703 mL
	40 mM	0.0741 mL	0.3705 mL	0.7411 mL	1.8527 mL
	50 mM	0.0593 mL	0.2964 mL	0.5929 mL	1.4822 mL
	60 mM	0.0494 mL	0.2470 mL	0.4941 mL	1.2352 mL
	80 mM	0.0371 mL	0.1853 mL	0.3705 mL	0.9264 mL
	100 mM	0.0296 mL	0.1482 mL	0.2964 mL	0.7411 mL

iBu-dG Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

iBu-dG68892-42-2N2-Isobutyryl-2'-deoxyguanosineNucleoside Antimetabolite/AnalogDNA/RNA Synthesisnucleoside analogoligoribonucleotidesInhibitorinhibitorinhibit

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