Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
All Product Categories
-
Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
-
DMT-2'-F-iBu-G
0 ImagesCat. No.: HY-W115309CAS No.: 144089-96-3Synonyms: 5'-DMT-2'-F-ibu-dGDMT-2'-F-iBu-G (5'-DMT-2'-F-ibu-dG) is a modified oligonucleotide. 2'-deoxy-2'-fluoro-modified oligonucleotides shows high nuclease resistant and retained exceptional binding affinity to the RNA targets.
-
Dmt-2'-f-dc(ac) amidite
0 ImagesSynonyms: 2'-F-Ac-dC Phosphoramidite; DMT-2′Fluoro-dC(ac) PhosphoramiditeDmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides.
-
5'-O-DMT-2'-TBDMS-Uridine
0 Images5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.
-
DMT-2'O-MOE-rG(ib) Phosphoramidite
0 ImagesCat. No.: HY-104014CAS No.: 251647-55-9DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides.
-
5-Methyl-2′-O-methylcytidine
0 Images5-Methyl-2′-O-methylcytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
1,3,5-Tri-O-benzoyl-a-D-ribofuranose
0 Images1,3,5-Tri-O-benzoyl-a-D-ribofuranose is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
Spongosine
0 ImagesCat. No.: HY-105006CAS No.: 24723-77-1Synonyms: 2-Methoxyadenosine; 2-O-MethylisoguanosineSpongosine (2-Methoxyadenosine) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
DMT-2'Fluoro-DG(IB) Amidite
0 ImagesSynonyms: 2'-F-ibu-dG PhosphoramiditeDMT-2'Fluoro-DG(IB) Amidite (2'-F-ibu-dG Phosphoramidite) is a nucleoside that can be employed for oligonucleotide synthesis. DMT-2'Fluoro-DG(IB) Amidite can be used to prepare 4'-modified 2'-deoxy-2'-fluorouridine.
-
2′-Deoxy-N-methylguanosine
0 Images2’-Deoxy-N2-methylguanosine, DNA adduct is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
6-Methylmercaptopurine riboside
0 Images6-Methylmercaptopurine riboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone
0 Images2,3,5-Tri-O-benzyl-D-ribono-1,4-lactone is a nucleoside analog.
-
L-Threonolactone
0 ImagesSynonyms: (3R,4S)-3,4-Dihydroxyoxolan-2-oneL-Threonolactone ((3R,4S)-3,4-Dihydroxyoxolan-2-one) is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
5-Bromocytidine
0 ImagesCat. No.: HY-W022290CAS No.: 3066-86-25-Bromocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
Cytidine-d2
0 ImagesCat. No.: HY-B0158SCAS No.: 40632-25-5Synonyms: Cytosine β-D-riboside-d2; Cytosine-1-β-D-ribofuranoside-d2
-
5-Hydroxyuridine
0 Images5-Hydroxyuridine (OHUrd) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
3'-Deoxycytidine
0 Images4-Amino-1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (3'-Deoxycytidine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
-
2-Amino-9-β-D-ribofuranosylpurine
0 ImagesSynonyms: 9-Pentofuranosyl-9H-purin-2-amine(2R,3R,4S,5R)-2-(2-amino-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol (9-pentofuranosyl-9H-purin-2-amine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
