Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2437)
Related Products (2437)
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Fluorescein-12-dUTP sodium solution (1 mM)
0 ImagesCat. No.: HY-178588AFluorescein-12-dUTP (sodium) solution (1 mM) is a fluorescent labeling and detection reagent that can be used for nucleic acid synthesis. Fluorescein-12-dUTP (sodium) solution (1 mM) can be used to synthesize labeled DNA probes for in situ hybridization, microarray or western blot analysis.
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Cytidine-13C
0 ImagesSynonyms: Cytosine β-D-riboside-13C; Cytosine-1-β-D-ribofuranoside-13C
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Cyclopentenylcytosine
0 ImagesSynonyms: CPEC; NSC 375575Cyclopentenylcytosine (CPEC), a carbocyclic nucleoside analog of cytosine, is a potent inhibitor of CTP synthetase and causes depletion of CTP and dCTP pools. Cyclopentenylcytosine shows broad-spectrum (both DNA and RNA viruses) antiviral activity. Cyclopentenyl cytosine increases Gemcitabine (HY-17026) radiosensitisation in human pancreatic cancer cells. Cyclopentenylcytosine shows effective antiviral activity in the Ad5/NZW rabbit ocular replication model and shows anti-tumor activity in various tumor xenografts model. Cyclopentenylcytosine can be used for the study of infection and cancer.
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Brivoligide sodium
0 ImagesCat. No.: HY-157549APurity: 99.37%Synonyms: AYX1 sodiumBrivoligide (AYX1) sodium is a double-stranded, unprotected, 23 base-pair oligonucleotide. Brivoligide sodium can reduce acute post-surgical pain. Brivoligide sodium mimics the DNA sequence normally bound by EGR1 on chromosomes.
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Adenosine-13C10,15N5
0 ImagesAdenosine-13C10,15N5 is the 13C and 15N labeled Adenosine (HY-B0228). Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physiology, including neuronal activity, vascular function, platelet aggregation, and blood cell regulation.
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2'-C-methyluridine
0 ImagesCat. No.: HY-W020098CAS No.: 31448-54-1
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2,3-O-Isopropylidene-D-ribonolactone
0 Images2,3-O-Isopropylidene-D-ribonolactone is an acetonide derivative of d-ribonolactone and an intermediate in organic synthesis.2,3-O-Isopropylidene-D-ribonolactone forms via acid-catalyzed acetalization of d-ribonolactone with acetone.2,3-O-Isopropylidene-D-ribonolactone facilitates production of 1,5-dideoxy-1,5-imino-d-ribitol and 1,5-dideoxy-1,5-imino-l-arabinitol.
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1-Methylinosine-d3
0 ImagesCat. No.: HY-113139SPurity: 99.0%Synonyms: N1-Methylinosine-d31-Methylinosine-d3 (N1-MetHYlinosine-d3) is the deuterium labeled 1-Methylinosine. 1-Methylinosine is a modified nucleotide located at position 37 of eukaryotic tRNA, 3' to the tRNA anticodon. 1-Methylinosine is a minor metabolite of 1-methyladenosine (HY-113081). The level of 1-Methylinosine is significantly elevated in urine samples from breast cancer models.
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2,8-Dimethyladenosine
0 Images2,8-Dimethyladenosine is an adenosine analogue. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. The popular products in this series are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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2’-O,4’-C-Methyleneuridine
0 Images2’-O,4’-C-Methyleneuridine (Compound 15a) is a bicyclic nucleoside.
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8-Methyl-2’-deoxyadenosine
0 ImagesCat. No.: HY-154241CAS No.: 85562-60-38-Methyl-2’-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine
0 ImagesCat. No.: HY-152378CAS No.: 908129-24-82’-Deoxy-2’-fluoro-β-D-arabino-6-azauridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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8-Methyladenosine
0 ImagesCat. No.: HY-152296CAS No.: 56973-12-78-Methyladenosine is a modified adenosine nucleoside. Through methylation at the 8-position, 8-Methyladenosine confers bacterial resistance to five classes of antibiotics that bind to the ribosomal peptidyl transferase center. 8-Methyladenosine can be used in studies of antibiotic-resistant bacterial infections.
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N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine
0 ImagesSynonyms: 5'-O-DMT-N4-Bz-dCN4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine (5'-O-DMT-N4-Bz-dC) can be used for synthesis oligodeoxynucleotides containing a 3'-S-phosphorothiolate (3'-PS) linkage. N4-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxycytidine is an useful tool for probing enzyme-catalyzed cleavage processes in DNA.
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2-Iodoadenosine
0 Images2-Iodoadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
