Nucleoside Antimetabolite/Analog
Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.
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Nucleoside Antimetabolite/Analog Related Products (2436)
Related Products (2436)
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2′-Deoxy-6-thioinosine
0 Images2′-Deoxy-6-thioinosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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8-Benzyloxy-3’-deoxy-3’-fluoroguanosine
0 ImagesCat. No.: HY-152359CAS No.: 2389988-61-68-Benzyloxy-3’-deoxy-3’-fluoroguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine
0 ImagesCat. No.: HY-152988CAS No.: 2243974-78-7N2-iso-Butyroyl-7'-O-DMT-morpholinoguanine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
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3’-Deoxy-3’-α-C-methylguanosine
0 ImagesCat. No.: HY-152428CAS No.: 444020-69-33’-Deoxy-3’-α-C-methylguanosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-3’-fluorouridine
0 ImagesCat. No.: HY-154607CAS No.: 129015-60-73’-Deoxy-5’-O-(4,4’-dimethoxytrityl)-3’-fluorouridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxy-2'-fluoro-N4-benzoyl-5-methylcytidine
0 ImagesCat. No.: HY-49198CAS No.: 182495-81-42'-Deoxy-2'-fluoro-N4-benzoyl-5-methylcytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1,3-Dimethyl pseudouridine
0 ImagesCat. No.: HY-152837CAS No.: 64272-68-01,3-Dimethyl pseudouridine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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7,8-Dihydro-8-oxo-7-propargyl guanosine
0 ImagesCat. No.: HY-152352CAS No.: 2763084-98-47,8-Dihydro-8-oxo-7-propargyl guanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7,8-Dihydro-8-oxo-7-propargyl guanosine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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6-Chloro-2-iodo-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine
0 ImagesCat. No.: HY-W010757CAS No.: 5987-76-86-Chloro-2-iodo-9-(2’,3’,5’-tri-O-acetyl-β-D-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-O-Acetyl-5’-O-benzoyl-3’-O-methyl-5-methyl uridine
0 ImagesCat. No.: HY-154550CAS No.: 2305415-91-0
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1,3'-Dimethylguanosine
0 ImagesCat. No.: HY-152602CAS No.: 74466-66-31,3'-Dimethylguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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3,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide
0 ImagesCat. No.: HY-152604CAS No.: 356782-84-83,4-Dihydro-3-oxo-4-β-D-ribofuranosyl-2-pyrazinecarboxamide is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)uridine
0 ImagesCat. No.: HY-154381CAS No.: 2095417-41-55’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)uridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2'-Deoxy-2'-fluoroarabino inosine
0 ImagesCat. No.: HY-154204CAS No.: 98983-40-52’-Deoxy-2’-fluoroarabino inosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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2’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine
0 ImagesCat. No.: HY-1523352’-Chloro-N6-(3-trifluoromethyl)benzyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
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1-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine
0 ImagesCat. No.: HY-1523961-(β-D-Xylofuranosyl)-N6-(m-methoxybenzyl)adenine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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m7GpppGmpG
0 ImagesCat. No.: HY-145977CAS No.: 1258049-00-1m7GpppGmpG is a trinucleotide 5′ cap analog with the capping efficiencies for the obtained RNAs of 86%.
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4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine
![4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine](https://file.medchemexpress.com/product_pic/hy-152986.gif "Click to View 4-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine Product Detail")
0 ImagesCat. No.: HY-152986CAS No.: 178995-71-64-Chloro-7-(2-deoxy-β-D-erythro-pentofuranosyl)-5-iodo-7H-pyrrolo[2,3-d]pyrimidine is a pyrimidine nucleoside analog. Pyrimidine nucleoside analogs have a wide range of biochemical and anticancer activities. These include DNA synthesis inhibition, RNA synthesis inhibition, antiviral effects, and immunomodulatory effects.
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2-(4-Methylbenzyl)thioadenosine
0 ImagesCat. No.: HY-154521CAS No.: 2095417-16-42-(4-Methylbenzyl)thioadenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
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2'-Deoxy-5'-O-DMT-N4-Fmoc-5-methylcytidine
0 ImagesCat. No.: HY-152978CAS No.: 176755-86-5
