PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Biotin-PEG5-amine
0 ImagesCat. No.: HY-140896CAS No.: 113072-75-6
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Bis-Biotin-PEG23
0 ImagesCat. No.: HY-140929CAS No.: 293298-36-9
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m-PEG6-thiol
0 ImagesCat. No.: HY-141329CAS No.: 441771-60-4
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m-PEG6-CH2CH2CHO
0 ImagesCat. No.: HY-W035376CAS No.: 1058691-77-2m-PEG6-CH2CH2CHO is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). m-PEG6-CH2CH2CHO is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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m-PEG5-CH2CH2COOH
0 ImagesCat. No.: HY-W043840CAS No.: 1347750-72-4
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DBCO-NHCO-PEG4-amine
0 ImagesCat. No.: HY-124386CAS No.: 1255942-08-5
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Tetrazine-Ph-NHCO-C3-NHS ester
0 ImagesTetrazine-Ph-NHCO-C3-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-NHCO-C3-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Azido-PEG3-SS-PEG3-azide
0 ImagesAzido-PEG3-SS-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG3-SS-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Boc-cis-4-hydroxy-L-proline
0 ImagesCat. No.: HY-W002886CAS No.: 87691-27-8N-Boc-cis-4-hydroxy-L-proline is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
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Hydroxy-PEG2-C2-PFP ester
0 ImagesCat. No.: HY-130488CAS No.: 1820673-42-4
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1-Cbz-3-Hydroxyazetidine
0 Images1-Cbz-3-Hydroxyazetidine is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-3-Hydroxyazetidine is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
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Mal-PEG8-alcohol
0 ImagesCat. No.: HY-140970CAS No.: 2353409-63-7
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NH-bis(PEG2-propargyl)
0 ImagesCat. No.: HY-140088CAS No.: 2100306-83-8
