Phosphodiesterase (PDE) Modulator

BRD9500 is an orally active phosphodiesterases 3 (PDE3) inhibitor with IC₅₀s of 10 and 27 nM for PDE3A and PDE3B, respectively. Antitumor activity.

Autotaxin modulator 1 is an autotaxin (ATX) enzyme inhibitor, extracted from patent WO 2014018881 A1, Compound Example 12b. Autotaxin modulator 1 is expected to be useful for researching demyelination due to injury or disease, as well as for researching proliferative disorders such as cancer.

BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1.

Nauclefine is an indole alkaloid isolated from Nauclea officinalis. Nauclefine acts as a PDE3A modulator to induce cancer cell apoptosis through a PDE3A-SLFN12-dependent death pathway.

BIO-32546 (Standard) is the analytical standard of BIO-32546 (HY-103035). This product is intended for research and analytical applications. BIO-32546 (example 12b, S-isomer) is an autotaxin (ATX) modulator (IC₅₀: 1 nM), extracted from the patent US20170158687A1.

6-Cl-cPuMP (sodium) is a cAMP analog with active chlorine function. 6-Cl-cPuMP (sodium) has good membrane permeability and phosphodiesterase (PDE) stability. 6-Cl-cPuMP (sodium) can be used for nervous system research.