2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Cyclin G-associated Kinase (GAK)
  5. Cyclin G-associated Kinase (GAK) Inhibitor

Cyclin G-associated Kinase (GAK) Inhibitor

Cyclin G-associated Kinase (GAK) Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-117626
    LP-935509
    		Inhibitor 99.74%
    LP-935509 is an orally active, potent, selective, ATP-competitive and brain-penetrant inhibitor of adaptor protein-2 associated kinase 1 (AAK1) with an IC50 of 3.3 nM and a Ki of 0.9 nM, respectively. LP-935509 is also a potent inhibitor of BIKE (IC50=14 nM) and a modest inhibitor of GAK (IC50=320 nM). LP-935509 shows antinociceptive activity. LP-935509 can be used for neuropathic pain and SARS-CoV-2 research.
  • HY-101290A
    BMT-090605 hydrochloride
    		Inhibitor 99.09%
    BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain.
  • HY-114569
    6-CEPN
    		Inhibitor 99.17%
    6-CEPN is a RAS inhibitor. 6-CEPN can inhibit RAS activation by binding to Icmt binding sites. 6-CEPN has anticancer activity. 6-CEPN can block cancer cells in the G1 phase. 6-CEPN can induce autophagy and necrosis of Cancer cells (Icmt: isovalerylcysteine carboxymethyltransferase).
  • HY-147258
    Culmerciclib
    		Inhibitor 98.09%
    Culmerciclib is a cyclin dependent kinase (CDK) inhibitor, and has antineoplastic activity.
  • HY-147258A
    Culmerciclib maleate
    		Inhibitor 99.52%
    Culmerciclib maleate is a cyclin dependent kinase (CDK) inhibitor, and has antineoplastic activity.