Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4010)
Related Products (4010)
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3,4-Dimethoxy-α-pyrrolidinopropiophenone hydrochloride
0 ImagesCat. No.: HY-W725184CAS No.: 28117-93-33,4-Dimethoxy-α-pyrrolidinopropiophenone hydrochloride is a drug derivative.
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3'-O-Methyl-(-)-epicatechin gallate
0 ImagesCat. No.: HY-N19627CAS No.: 607357-35-7Synonyms: 3′-M-ECG3'-O-Methyl-(-)-epicatechin gallate (3′-M-ECG) is a methylated Catechin (HY-N0898) derivative and is an antioxidant agent. 3'-O-Methyl-(-)-epicatechin gallate reduces oxygen consumption and prevents decreases in linoleic and α-linolenic acids to protect canola oil from lipid oxidation when heated.
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Benzedrone hydrochloride
0 ImagesCat. No.: HY-129281CAS No.: 1797979-43-1Benzedrone hydrochloride is an analog of Mephedrone characterized by the replacement of the amino methyl group with a benzyl moiety.
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Geranyl-L-Cysteine
0 ImagesCat. No.: HY-N15761CAS No.: 71050-10-7
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3',4'-Dihydroxytrimethoprim
0 ImagesCat. No.: HY-W716241CAS No.: 71525-06-93',4'-Dihydroxytrimethoprim is a Trimethoprim (HY-B0510) derivative. 3',4'-Dihydroxytrimethoprim forms via sequential O-demethylation of Trimethoprim in human liver microsomes. 3',4'-Dihydroxytrimethoprim can be used for metabolic research.
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1-(2-Fluorophenyl)piperazine hydrochloride
0 ImagesCat. No.: HY-W715044CAS No.: 76835-09-11-(2-Fluorophenyl)piperazine hydrochloride is categorized as a piperazine.
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N-Nitrosodiisobutylamine
0 ImagesCat. No.: HY-W653713CAS No.: 997-95-5N-Nitrosodiisobutylamine is an alkyl derivatives of N-nitrosodiethylamine, and does not have significant carcinogenic effect.
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Brovanexine hydrochloride
0 ImagesCat. No.: HY-164021CAS No.: 54340-60-2Synonyms: BR-222; UR389Brovanexine hydrochloride (BR-222; UR389) is an expectorant, which reduces the adsorption capacity of sputum and ameliorates lung ventilation function.
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N-Nitrosobis(2-oxopropyl)amine
0 ImagesCat. No.: HY-W209580CAS No.: 60599-38-4N-Nitrosobis (2-oxopropyl) amine is a nitrosamine compound that has been the subject of significant research interest in the field of chemical carcinogenesis. N-nitrosobis (2-oxopropyl) amine (BOP) -treated Syrian golden hamsters are a chemical carcinogenesis model that represents human pancreatic cancer.
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(±)-Threo-4-methylmethylphenidate hydrochloride
0 ImagesCat. No.: HY-168827CAS No.: 680996-70-7(±)-Threo-4-methylmethylphenidate hydrochloride is a phenethylamine.
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Cetamolol
0 ImagesCat. No.: HY-101434CAS No.: 34919-98-7Synonyms: AI-27303; ICI-72222Cetamolol is an active compound.
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WAY-359473
0 ImagesCat. No.: HY-157178CAS No.: 314248-20-9WAY-359473 is an active molecule.
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14,15-EE-8(Z)-E
0 ImagesCat. No.: HY-165067CAS No.: 519038-93-8Synonyms: 14,15-Epoxyeicosa-8(Z)-enoic acid14,15-EE-8(Z)-E (14,15-Epoxyeicosa-8(Z)-enoic acid) has potent vasodilator agonist activity in bovine coronary arteries. 14,15-EE-8(Z)-E is a 14,15-EET (HY-113489) analog. EETs represent important mediators of coronary vascular tone.
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5-MeO-NBpBrT
0 ImagesCat. No.: HY-180495CAS No.: 155639-13-7Synonyms: 5MT-NB4B5-MeO-NBpBrT (Compound 2f) (5MT-NB4B) is a NBOMe derivative and 5MT-based N-(bromobenzyl) isomer.
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2-Methoxy-3-methylcarbazole
0 Images2-Methoxy-3-methylcarbazole is a natural carbazole alkaloid.
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4-Cl-Benzodioxolyl chalcone
0 ImagesCat. No.: HY-181638CAS No.: 934022-22-74-Cl-Benzodioxolyl chalcone is a type of chalcone. It reduces the viability of endometriotic cells while maintaining or increasing the viability of normal endometrial cells. 4-Cl-Benzodioxolyl chalcone can be used in the research of endometriosis.
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4-Hydroxy DPT
0 ImagesCat. No.: HY-118802CAS No.: 63065-88-34-Hydroxy DPT is a tryptamine that induces the head-twitch response (HTR) in mice.
