FOXC1
FOXC1 is a transcription factors belonging to FOXC family. FOXC1 is an essential component in embryonic development of brain, eye and bone. FOXC1 knock-out mice die at birth with hydrocephalus, eye defects, and multiple skeletal abnormalities. FOXC1 is recently identified as a critical regulator for the niche formation of haematopoietic stem and progenitor cells, as well as hair follicle stem cells. Elevated expression of FOXC1 occur in a variety of cancers such as breast carcinoma, hepatocellular carcinomas, lymphoma and so on. FOXC1 promotes cancers through mediating cell proliferation, metastasis, epithelial–mesenchymal transition (EMT), angiogenesis and lymphangiogenesis[1].
