FOXJ2
FOXJ2 is a forkhead factor, belonging to the FOX family, with a dual DNA binding specificity. FOXJ2 is a transcription factor of this family that shows a rather broad expression pattern, both in the adult as well as during embryonic development, but the levels of expression vary between organs and, in each organ, not all cells types express the factor. Recent study has reported that upregulation of FOXJ2 might inhibit of cell migration and invasion of breast cancer. FOXJ2 is a transcription factor that has been reported to induce epithelial-mesenchymal transition (EMT). FOXJ2 mRNA and protein levels were downregulated in extrahepatic CC tissues compared to adjacent normal bile duct tissues[1].
