Isotope-Labeled Compounds
Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time.
MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.
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Isotope-Labeled Compounds Related Products (11051)
Related Products (11051)
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Glycocholic acid-d5
0 ImagesGlycocholic acid-d5 is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).
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Cytidine-5'-triphosphate-15N3 dilithium
0 ImagesCat. No.: HY-125818S6Synonyms: Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3 dilithiumCytidine-5'-triphosphate-15N3 (Cytidine triphosphate-15N3 dilithium; 5'-CTP-15N3) dilithium is 15N labeled Cytidine-5'-triphosphate (HY-125818). Cytidine 5′-triphosphate (Cytidine triphosphate; 5'-CTP) is a nucleoside triphosphate and serves as a building block for nucleotides and nucleic acids, lipid biosynthesis. Cytidine triphosphate synthase can catalyze the formation of cytidine 5′-triphosphate from uridine 5′-triphosphate (UTP). Cytidine 5′-triphosphate is an essential biomolecule in the de novo pyrimidine biosynthetic pathway in T. gondii.
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L-Asparagine-13C4,15N2,d8
0 ImagesL-Asparagine-13C4,15N2,d8 is the 13C-labeled and 15N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
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Spironolactone-d3
0 ImagesCat. No.: HY-B0561S1Purity: 99.82%Synonyms: SC9420-d3Spironolactone-d3 is the deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC50 of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC50 of 77 nM. Spironolactone promotes autophagy in podocytes.
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Docosahexaenoic acid ethyl ester-d5-1
0 ImagesCat. No.: HY-107343S1CAS No.: 159146-01-7Synonyms: Ethyl docosahexaenoate-d5-1Docosahexaenoic acid ethyl ester-d5-1 is the deuterium labeled Docosahexaenoic acid ethyl ester. Docosahexaenoic acid ethyl ester (Ethyl docosahexaenoate) is a 90% concentrated ethyl ester of docosahexaenoic acid manufactured from the microalgal oil. Docosahexaenoic acid ethyl ester enhances 6-hydroxydopamine-induced neuronal damage by induction of lipid peroxidation in mouse striatum. Docosahexaenoic acid (DHA) is a key component of the cell membrane, and its peroxidation is inducible due to the double-bond chemical structure. Docosahexaenoic acid has neuroprotective effects.
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2,3,4'-Trichlorobiphenyl-d4
0 ImagesCat. No.: HY-W414846SSynonyms: PCB NO 22-d42,3,4'-Trichlorobiphenyl-d4 is the deuterium labeled 2,3,4'-Trichlorobiphenyl.
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1-Methyl-4-nitrosopiperazine-d11
0 ImagesCat. No.: HY-W726845Synonyms: MNP-d11; MeNP-d11; N-Methyl-N'-nitrosopiperazine-d111-Methyl-4-nitrosopiperazine-d11 (MNP-d11) is the deuterium labeled 1-Methyl-4-nitrosopiperazine (HY-W663740). 1-Methyl-4-nitrosopiperazine (MNP; MeNP;N-Methyl-N'-nitrosopiperazine) is a potential impurity in sartans, non-steroidal anti-inflammatory drugs (NSAIDs), and thiazide diuretics.
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Tucidinostat-d4
0 ImagesSynonyms: Chidamide-d4; HBI-8000-d4; CS 055-d4
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Cycloguanil-d6
0 ImagesSynonyms: Chlorguanide triazine-d6Cycloguanil-d6 (Chlorguanide triazine-d6) is the deuterium labeled Cycloguanil (HY-12784). Cycloguanil is a dihydrofolate reductase (DHFR) inhibitor with an IC50 of 10.8 μM against human DHFR. Cycloguanil blocks the folate metabolic pathway, thereby affecting nucleotide synthesis and interfering with DNA replication. Cycloguanil inhibits DHFR in Plasmodium and is thus used in malaria research. Cycloguanil also potently inhibits DHFR in human cancer cells and blocks the transcriptional activity of STAT3, thereby exhibiting anticancer activity.
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Triciribine phosphate-d3
0 ImagesCat. No.: HY-10250S1Synonyms: TCN-P-d3Triciribine phosphate-d3 (TCN-P-d3) is a deuterated compound of Triciribine phosphate (TCN-P). TCN-P inhibits adenosine monophosphate (AMP)-activated protein kinase through an allosteric mechanism, affecting the first key step in de novo purine biosynthesis. Triciribine phosphate also inhibits inosine monophosphate dehydrogenase, which is the first key step in guanosine nucleotide synthesis. Triciribine phosphate does not affect ligase activity .
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C22 Glucosylceramide (d18:1/22:0)-d4
0 ImagesC22 Glucosylceramide (d18:1/22:0)-d4 is deuterium labeled C22 Glucosylceramide (d18:1/22:0) (HY-164236). C22 Glucosylceramide (d18:1/22:0) is a bioactive sphingolipid composed of a d18:1 sphingoid base and a 22:0 fatty acid chain. C22 Glucosylceramide (d18:1/22:0) specifically exists in Doxorubicin (HY-15142A)-sensitive cancer cells, and its circulating concentration is positively correlated with the incidence of cardiovascular events. C22 Glucosylceramide (d18:1/22:0) has been widely used in research related to cardiovascular diseases, hypercholesterolemia, metabolic syndrome, breast adenocarcinoma and other fields.
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Orotic acid-15N2 hydrate
0 ImagesCat. No.: HY-W016812SOrotic acid-15N2 is the 15N hydrate labeled Orotic acid hydrate. Orotic acid hydrate is an endogenous metabolite.
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Cholestenone-13C2
0 ImagesSynonyms: 4-Cholesten-3-one-13C2Cholestenone-13C2 is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
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Clindamycin-13C,d3
0 ImagesClindamycin-13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria.
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1-Eicosanol-d41
0 ImagesSynonyms: Arachidyl alcohol-d411-Eicosanol-d41 (Arachidyl alcohol-d41) is the deuterium labeled 1-Eicosanol (HY-W004263). 1-Eicosanol is a natural compound with antioxidant activity found in Justicia insularis leaves. 1-Eicosanol can be used as an antioxidant.
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Sodium 2-oxobutanoate-13C4
0 ImagesSodium 2-oxobutanoate-13C4 is the 13C labeled Sodium 2-oxobutanoate.
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Isradipine-d3
0 ImagesCat. No.: HY-B0233SCAS No.: 1189959-59-8Isradipine-d3 (PN 200-110-d3) is the deuterium labeled Isradipine. Isradipine (PN 200-110) is an orally active L-type calcium channel blocker. Isradipine, as a powerful peripheral vasodilator, is a dihydropyridine calcium antagonist with selective actions on the heart as well as the peripheral circulation. Isradipine is a potentially viable neuroprotective agent for Parkinson's disease.
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Sodium butyrate-d3
0 ImagesSynonyms: Butanoic acid-d3 sodium; Butyric acid-d3 sodiumSodium butyrate-d3 (Butanoic acid-d3 sodium) is the deuterium labeled Sodium butyrate (HY-B0350A). Sodium Butyrate (sodium butanoate) is an inhibitor of HDAC, possessing anti-tumor activity.
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Clencyclohexerol-d10
0 ImagesClencyclohexerol-d10 is the deuterium-labeled Clencyclohexerol (HY-117406). Clencyclohexerol-d10 is a β-agonist. Clencyclohexerol-d10 can be used as a growth promoter in animals.
