LAG-3

Lymphocyte activation gene-3; CD223

Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases^[1]^[2]^[3].

References:

[1]. Mariuzza RA, Shahid S, Karade SS. The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy. J Biol Chem. 2024 May;300(5):107241. [Content Brief]

[2]. Aggarwal V, et al. LAG-3 as the third checkpoint inhibitor. Nat Immunol. 2023 Sep;24(9):1415-1422. [Content Brief]

[3]. Ren K, et al. Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials. Front Immunol. 2024 Nov 26;15:1501613. [Content Brief]

LAG-3 Related Products (45)
Antibodies (1)

By Effects:	Inhibitors (26) Degraders (2) Ligands (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-180900

Z3071585108	Ligand
Z3071585108 is a small molecule binder of the LAG-3 D1 domain with K_d values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3.

HY-P991300

GSK2831781	Inhibitor
GSK2831781 is a human IgG1 monoclonal antibody (mAb) targeting CD223/LAG3. GSK2831781 can be used in the study of ulcerative colitis Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992156

Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853)	Inhibitor
Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) is a monoclonal antibody that specifically binds to human, mouse and bovine LAG-3. Anti-Human/Mouse/Bovine LAG-3 Antibody (ADI-31853) can be used in the research of colon cancer, colorectal cancer and rectal cancer. The recommended isotype control is Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-108691R

PF-06465469 (Standard)	Inhibitor
PF-06465469 (Standard) is the analytical standard of PF-06465469 (HY-108691). This product is intended for research and analytical applications. PF-06465469 is a covalent inhibitor of ITK with an IC₅₀ of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma.

HY-P990204

Anti-Mouse LAG-3 (D265A) Antibody (C9B7W)	Inhibitor
Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) is a chimeric antibody of the original C9B7W antibody (HY-P99141). Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) contains the D265A mutation region. Anti-Mouse LAG-3 (D265A) Antibody (C9B7W) can be used for research on cancer.

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LAG-3

LAG-3 Related Products (45)

Antibodies (1)

LAG-3 Related Products (45):