LAG-3 Inhibitor

Anti-Mouse LAG-3 Antibody (C9B7W) is an anti-mouse LAG-3 IgG1 monoclonal antibody. Anti-Mouse LAG-3 Antibody (C9B7W) can enhance CD4⁺ T cell function and exert anti-tumor effects without blocking the interaction between LAG-3 and MHCII. Anti-Mouse LAG-3 Antibody (C9B7W) can be used for research on cancer such as head and neck squamous cell carcinoma (HNSCC).

PF-06465469 is a covalent inhibitor of ITK with an IC₅₀ of 2 nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma.

IMP-761 is a human IgG4 monoclonal antibody (mAb) targeting CD223/LAG3. IMP-761 binds to D1 of human LAG32. Recommend Isotype Controls: Human IgG4 kappa, Isotype Control (HY-P99003).

RBN013209 is an orally active small molecule inhibitor of CD38 with an IC₅₀ of 0.01 to 0.1 μM for human CD38. RBN013209 prevents the conversion of extracellular NAD⁺ to ADPR or cADPR in tumor cells and PBMCs. RBN013209 can be used in the study of tumor. In addition, RBN013209 enables CAR-T cells to maintain the naive state and central memory state, and decreases the expression of cell activation markers and exhaustion-related inhibitory receptors.

CPI-644 is a selective EP300/CBP bromodomain inhibitor, with an IC₅₀ of 0.18 µM against the CBP bromodomain. CPI-644 reduces the proportion of FOXP3⁺ cells and downregulates the expression of LAG-3, CTLA-4 and PD-1. CPI-644 can be used in cancer-related research.

LAGi-DEL is a LAG-3 inhibitor, with K_d values of 97.33 nM and 271 nM in surface plasmon resonance (SPR) assay and microscale thermophoresis (MST) assay, respectively. LAGi-DEL blocks the LAG-3/MHC-II interaction, with an EC₅₀ of 138 nM. LAGi-DEL restores T cell activation, enhances IFN-γ secretion and promotes immune-mediated cytotoxicity. LAGi-DEL can be used in the research of acute myeloid leukemia, lung cancer and melanoma.

SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors.

Encelimab is an anti-LAG3 antibody. Encelimab blocks the interaction between LAG-3 and MHC II, and enhances T-cell activation. Encelimab alone or in combination with an anti-PD-1 antibody reduces tumor size in a lymphoma mice model (A20 cell xenograft).

LAG-3 Hit II is a LAG-3 inhibitor with a K_D of 4.32  μM. LAG-3 Hit II can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.

SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC₅₀ values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.

LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC₅₀ value of 4.45 μM and a K_i value of 2.66 µM.

KL-A289 is a human monoclonal antibody (mAb) targeting CD223/LAG3. KL-A289 can be used in the study of metastatic GC.

AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors.

DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3.

LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a K_d value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8⁺ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.

LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a K_D of 0.41  μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.

LAG-3-IN-2 (Compound LG-17) is a LAG-3 inhibitor. LAG-3-IN-2 can be used for the study of immunology.

TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma.

Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with K_d values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).

Anti-Bovine LAG-3 Antibody (2D8) is an antibody targeting Bovine LAG-3. The isotype control for Anti-Bovine LAG-3 Antibody (2D8) can be referenced as Rat IgG1 kappa, Isotype Control (HY-P99979).