LAGi-DEL
LAGi-DEL is a LAG-3 inhibitor, with Kd values of 97.33 nM and 271 nM in surface plasmon resonance (SPR) assay and microscale thermophoresis (MST) assay, respectively. LAGi-DEL blocks the LAG-3/MHC-II interaction, with an EC50 of 138 nM. LAGi-DEL restores T cell activation, enhances IFN-γ secretion and promotes immune-mediated cytotoxicity. LAGi-DEL can be used in the research of acute myeloid leukemia, lung cancer and melanoma.
For research use only. We do not sell to patients.
- Formula: C28H26N4O5S
- Molecular Weight:530.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
LAGi-DEL (10 μM; 24 h) restores T cell activation, elevates IFN-γ secretion, and promotes immune-mediated killing of THP-1 human acute myeloid leukemia cells in a PBMC co-culture model[1].
LAGi-DEL (10 μM; 24 h) restores T cell activation, elevates IFN-γ secretion, and promotes immune-mediated killing of A549 human lung carcinoma cells in a PBMC co-culture model[1].
LAGi-DEL exhibits favorable drug-like properties including high aqueous solubility, moderate permeability, acceptable metabolic and plasma stability, low cytotoxicity to normal cells, negligible hERG and CYP liabilities, and no mutagenic activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 530.59
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Formula C28H26N4O5S
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SMILES
CNC(C[C@H](C1=CC(OC)=CC(OC)=C1)NC(C2=C(NC(N3)=O)C3=CC(C4=C(SC=C5)C5=CC=C4)=C2)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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