LAG-3
Lymphocyte activation gene-3; CD223
Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases[1][2][3].
References:
- [1]. Mariuzza RA, Shahid S, Karade SS. The immune checkpoint receptor LAG3: Structure, function, and target for cancer immunotherapy. J Biol Chem. 2024 May;300(5):107241. [Content Brief]
- [2]. Aggarwal V, et al. LAG-3 as the third checkpoint inhibitor. Nat Immunol. 2023 Sep;24(9):1415-1422. [Content Brief]
- [3]. Ren K, et al. Lymphocyte-activation gene 3 in cancer immunotherapy: function, prognostic biomarker and therapeutic potentials. Front Immunol. 2024 Nov 26;15:1501613. [Content Brief]
All Product Categories
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LAG-3 Related Products (45)
Related Products (45)
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Antibodies (1)
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Cugrastomig
0 ImagesSynonyms: AK-129HY-P990912 is an PDCD1/LAG3-targeting IgG1κ-[scFv-heavy -κ]2 type chimeric human and humanized antibody.
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Anti-Mouse FGL-1 Antibody (177R4)
0 ImagesCat. No.: HY-P990243Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer.
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SA-15-P
0 ImagesSA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.
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KL-A289
0 ImagesCat. No.: HY-P991302KL-A289 is a human monoclonal antibody (mAb) targeting CD223/LAG3. KL-A289 can be used in the study of metastatic GC.
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AM0003
0 ImagesCat. No.: HY-P991297AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors.
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DNV-3
0 ImagesCat. No.: HY-P991298DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
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LAG-3 cyclic peptide inhibitor C25
0 ImagesCat. No.: HY-P10835LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8+ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.
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LAG-3-IN-1
0 ImagesCat. No.: HY-176814LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a KD of 0.41 μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.
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LAG-3-IN-2
0 ImagesCat. No.: HY-178320CAS No.: 724757-58-8LAG-3-IN-2 (Compound LG-17) is a LAG-3 inhibitor. LAG-3-IN-2 can be used for the study of immunology.
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SHR-1802
0 ImagesCat. No.: HY-P992461SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors.
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TQB-2223
0 ImagesCat. No.: HY-P991303Synonyms: Sym022; S 95017TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma.
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Anti-LAG-3 Antibody (BAP050)
0 ImagesCat. No.: HY-P992254Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with Kd values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
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ENUM006
0 ImagesCat. No.: HY-P991299ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
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Z3071585108
0 ImagesCat. No.: HY-180900CAS No.: 2249005-28-3Z3071585108 is a small molecule binder of the LAG-3 D1 domain with Kd values measured for the MST-TRIC channel and spectral shift detection of 59.2 and 56.1 μM respectively. Z3071585108 partially inhibits the binding of LAG-3 to MHCII, with an EC₅₀ of 42.9 μM. Z3071585108 can be used for the study of small molecule immunotherapies targeting LAG-3.
