2. Signaling Pathways
  3. Immunology/Inflammation
  4. LAG-3

LAG-3

Lymphocyte activation gene-3; CD223

Lymphocyte activation gene-3 (LAG-3) is an immune checkpoint protein that belongs to the immunoglobulin superfamily. LAG-3 is mainly expressed on activated T cells, NK cells, B cells and plasmacytoid dendritic cells. LAG-3 has a high affinity for MHC class II molecules and can also bind to FGL1. Binding of LAG-3 to its ligands leads to the inhibition of T cell activation and proliferation, thereby regulating the immune response. In the tumor microenvironment, overexpression of LAG-3 is often observed, which helps tumor cells escape immune surveillance. LAG-3 is considered as an important target for cancer immunotherapy. In addition to its role in tumor immunity, LAG-3 is also involved in the pathogenesis of some autoimmune diseases and infectious diseases[1][2][3].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P990740
    Fanastomig
    Fanastomig (EMB-02) is a bispecific antibody against PD-1/LAG3. Fanastomig exhibits potential immune checkpoint inhibitory activity and antineoplastic activity.
    Fanastomig
  • HY-P990912
    Cugrastomig
    		98.46%
    HY-P990912 is an PDCD1/LAG3-targeting IgG1κ-[scFv-heavy -κ]2 type chimeric human and humanized antibody.
    Cugrastomig
  • HY-162811
    LAG-3 biner 1
    LAG-3 biner 1 (compound 3) is a small molecule ligand (Kd=1.23 μM) for the immune checkpoint lymphocyte activation gene 3 (LAG-3). LAG-3 biner 1 can be used in the research of cancer diagnosis targeting LAG-3.
    LAG-3 biner 1
  • HY-P99354
    Bavunalimab
    		99.408%
    Bavunalimab (Anti-Human CTLA4xLAG3) is a bispecific human anti-CTLA-4/LAG-3 monoclonal antibody. Bavunalimab activates T cells in NSG mice. Bavunalimab can be used for the research of cancer.
    Bavunalimab
  • HY-P990243
    Anti-Mouse FGL-1 Antibody (177R4)
    		Ligand
    Anti-Mouse FGL-1 Antibody (177R4) is an anti-mouse FGL-1 IgG2a monoclonal antibody. Anti-Mouse FGL-1 Antibody (177R4) can increase CD8+ T cell infiltration. Anti-Mouse FGL-1 Antibody (177R4) enhances the anti-tumor immune effect by blocking FGL1. Anti-Mouse FGL-1 Antibody (177R4) can be used for research on cancer such as lung cancer and breast cancer.
    Anti-Mouse FGL-1 Antibody (177R4)
  • HY-164308
    SA-15-P
    		Inhibitor 99.62%
    SA-15-P inhibits LAG-3/MHCII and LAG-3/FGL1 interactions with IC50 values of 4.21 and 6.52 μM respectively. LAG-3/MHCII interaction is a target for immunotherapies.
    SA-15-P
  • HY-P10837
    LAG-3 cyclic peptide inhibitor 12
    		Inhibitor
    LAG-3 cyclic peptide inhibitor 12 (Cyclic peptide 12) is an inhibitor of LAG-3 with an IC50 value of 4.45 μM and a Ki value of 2.66 µM.
    LAG-3 cyclic peptide inhibitor 12
  • HY-P991302
    KL-A289
    		Inhibitor
    KL-A289 is a human monoclonal antibody (mAb) targeting CD223/LAG3. KL-A289 can be used in the study of metastatic GC.
    KL-A289
  • HY-P991297
    AM0003
    		Inhibitor
    AM0003 is a human monoclonal antibody (mAb) targeting CD223/LAG3. AM0003 can be used in the study of advanced solid tumors.
    AM0003
  • HY-P991298
    DNV-3
    		Inhibitor
    DNV-3 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
    DNV-3
  • HY-P10835
    LAG-3 cyclic peptide inhibitor C25
    		Inhibitor
    LAG-3 cyclic peptide inhibitor C25 is a LAG-3 inhibitor. LAG-3 cyclic peptide inhibitor C25 has a high affinity with human LAG-3 protein with a Kd value of 0.66 μM. LAG-3 cyclic peptide inhibitor C25 can block the interaction of LAG-3 with HLA-DR (MHC-II) and activate CD8+ T cells. LAG-3 cyclic peptide inhibitor C25 can be used in the study of cancer.
    LAG-3 cyclic peptide inhibitor C25
  • HY-176814
    LAG-3-IN-1
    		Inhibitor
    LAG-3-IN-1 (Compound 11) is a LAG-3 inhibitor with a KD of 0.41  μM. LAG-3-IN-1 disrupts the LAG-3/MHCII interaction, enhances IFN-γ secretion and promotes tumor cell killing in cocultures of PBMCs and cancer cells. LAG-3-IN-1 can be used for cancers like ovarian cancer, colon adenocarcinoma and melanoma research.
    LAG-3-IN-1
  • HY-179061
    LAG-3 degrader 1
    		Degrader
    LAG-3 degrader 1 is a PROTAC target protein ligand that can be used for synthesis of PROTACs, such as LAG-3 PROTAC-1 (HY-179060). LAG-3 PROTAC-1 is a potent LAG-3 PROTAC degrader with anti-tumor activity.
    LAG-3 degrader 1
  • HY-178320
    LAG-3-IN-2
    		Inhibitor
    LAG-3-IN-2 (Compound LG-17) is a LAG-3 inhibitor. LAG-3-IN-2 can be used for the study of immunology.
    LAG-3-IN-2
  • HY-P992461
    SHR-1802
    		Inhibitor
    SHR-1802 is a humanized anti-LAG-3 monoclonal antibody.SHR-1802 specifically binds to LAG-3 and inhibits its binding to major histocompatibility complex class II (MHC-II), fibrinogen-like protein 1 (FGL1), galectin-3, and liver sinusoidal endothelial cell lectin.SHR-1802 can be used for the research of advanced solid tumors.
    SHR-1802
  • HY-P991303
    TQB-2223
    		Inhibitor
    TQB-2223 is a human monoclonal antibody (mAb) targeting CD223/LAG3. TQB-2223 can be used in the study of Hodgkin lymphoma.
    TQB-2223
  • HY-P991605
    HLX26
    		Inhibitor
    HLX26 is a humanised anti-LAG-3 monoclonal antibody. HLX26 has antitumor activity especially advanced solid tumours. HLX26 can be used for lymphoma research.
    HLX26
  • HY-P992254
    Anti-LAG-3 Antibody (BAP050)
    		Inhibitor
    Anti-LAG-3 Antibody (BAP050) is an anti-LAG3 antibody with Kd values of 9.0 nM (Equilibrium) and 0.80 nM (Kinetic) against hLAG3. Anti-LAG-3 Antibody (BAP050) binds to an epitope outside the 30-amino-acid residue loop in the first immunoglobulin-like domain (D1) of hLAG3. Anti-LAG-3 Antibody (BAP050) is applicable for cancer-related research. The isotype control is Mouse IgG1 kappa, Isotype Control (HY-P99977).
    Anti-LAG-3 Antibody (BAP050)
  • HY-P992075
    Anti-Bovine LAG-3 Antibody (2D8)
    		Inhibitor
    Anti-Bovine LAG-3 Antibody (2D8) is an antibody targeting Bovine LAG-3. The isotype control for Anti-Bovine LAG-3 Antibody (2D8) can be referenced as Rat IgG1 kappa, Isotype Control (HY-P99979).
    Anti-Bovine LAG-3 Antibody (2D8)
  • HY-P991299
    ENUM006
    		Inhibitor
    ENUM006 is a human monoclonal antibody (mAb) targeting CD223/LAG3.
    ENUM006
Cat. No. Product Name / Synonyms Application Reactivity