Liposome

Liposomes (NPs typically 100–500 nm in diameter) are fabricated from the self-assembly of phospholipids, which consist of a polar phosphate head group and hydrophobic lipid tails. In aqueous environments, the hydrophobic tails self-orient, resulting in a spherical structure comprised of an aqueous core surrounded by a lipophilic bilayer membrane. Liposomes are both biocompatible and biodegradable (e.g., at certain pH and temperature), which can be controlled by modifying the lipid composition. Furthermore, liposomes are amenable to various modifications that improve their efficacy as drug delivery carriers.

References:

[1]. Almeida B, Nag OK, Rogers KE, Delehanty JB. Recent Progress in Bioconjugation Strategies for Liposome-Mediated Drug Delivery. Molecules. 2020;25(23):5672. Published 2020 Dec 1. [Content Brief]

Liposome Related Products (1007):

By Effects:	Inhibitors (2) Controls (2) Substrate (1) Modulator (1) Chemicals (8)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-W440927

Stearic acid-PEG2000-NHS
Stearic acid-PEG2000-NHS is an amphiphatic PEG polymer which forms micelles in an aqueous solution for drug-loaded nanoparticles. The NHS ester is reactive with amine to form a stable amide bond. Reagent grade, for research purpose.

HY-172275A

DSPE-PEG2000-Cys-SRNLIDC (Disulfide bridge: Cys1-Cys8)
DSPE-PEG2000-pPB is a PEG compound which composed of DSPE and a cyclic oligopeptide (pPB). pPB has a strong binding affinity with PDGFRβ, which is overexpressed on activated hepatic stellate cells (HSC). DSPE-PEG2000-pPB can be used for drug delivery.

HY-W440834

DSPE-PEG5000-azide
DSPE-PEG5000-azide is a click chemistry reactive phospholipid polyPEG which forms lipid bilayer or micelles in an aqueous solution. The polymer can be used to prepare liposomes or nanoparticles used for delivering nutrients or therapeutic agents, for example mRNA or DNA vaccine.

HY-144768

(R)-Chol-TPP
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive.

HY-W590683

9A1P9		99.40%
9A1P9 is a multi-tail ionizable cationic phospholipid. 9A1P9 induces membrane destabilization. 9A1P9 can be used for mRNA delivery t.

HY-W800793

16:0 Succinyl PE		99.34%
16:0 Succinyl PE is a carboxylic acid-functionalized lipid with a two carbon linker to a phosphoethanolamine bound to two palmitic acid tails.

HY-157688

C18(Plasm) LPE		99.0%
C18(Plasm) LPE (PE(18:1p/0:0)) is a bioactive lipid with the activity of regulating cell signaling and promoting cell growth.

HY-160553

9322-O16B		99.7%
9322-O16B, an ionizable cationic lipid, is used for LNP generation.

HY-W322225

1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine		99.88%
1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine (DLPE) is a derivative of phosphatidylethanolamine with lauric acid (12:0) acyl chains. 1,2-Dilauroyl-sn-glycero-3-phosphoethanolamine can be used to synthesize liposomes.

HY-W440911

DSPE-PEG2000-Cy5		99.91%
DSPE-PEG2000-Cy5 is a Cy5 (HY-D0821) fluorophore-labeled conjugate of distearoylphosphatidylethanolamine and polyethylene glycol, as well as a liposome component. The Cy5 fluorophore is commonly used for labeling proteins and nucleic acids in imaging, flow cytometry and genomic applications. DSPE-PEG2000-Cy5 supports cell membrane modification, in vivo tumor targeting research and long-term in vivo circulation of its liposomal formulations (Ex/Em=633/670 nm).

HY-131652

1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine
1,2-Di-O-hexadecyl-sn-glycero-3-phosphocholine (16:0 Diether PC) is a synthetic ether-linked phospholipid containing hexadecyl groups at the sn-1 and sn-2 positions. It is commonly used in the generation of liposomes and artificial membranes to study membrane dynamics.

HY-173606

DSPE-PEG2000-Azide ammonium		99.9%
DSPE-PEG2000-Azide ammonium is an azide containing lipid that can be used to form micelles as nanoparticles for drug delivery. DSPE-PEG2000-Azide ammonium is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-159858

Lipid 16
Lipid 16 is an ionizable lipid that can be used to synthesize lipid nanoparticles (LNP) for delivering mRNA and other payloads. Lipid 16 as a potent cell type-specific ionizable lipid for the CD11bhi macrophage population without an additional targeting moiety.

HY-171158

Glycerophosphoglycerol	Control	99.76%
Glycerophosphoglycerol is a precursor for phospholipid biosynthesis. Glycerophosphoglycerol supports tumor cell membrane reconstruction and proliferation by promoting phospholipid synthesis. Glycerophosphoglycerol is promising for research of breast cancers.

HY-141629S2

N-Palmitoyl-D-sphingomyelin-d₉		99.9%
N-Palmitoyl-D-sphingomyelin-d₉ (Sphingomyelin 16:0-d₉) is deuterium labeled N-Palmitoyl-D-sphingomyelin. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles.

HY-160554

C12-113		98.67%
C12-113 is a lipidoid delivery agent that can be used to transfect siRNA into cells. C12-113 can also be combined with other lipids to form lipid nanoparticles (LNPs) for the delivery of mRNA encoding the spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in mice.

HY-W440917

DSPE-PEG5000-FITC		98.09%
DSPE-PEG5000-FITC is a fluorescein attached PEG lipid. It can be used to prepare liposomes as drug carrier in targeted drug delivery. The polymer is modified with fluorescein (green) dye which can be used for staining cells, tissues, biomarkers, or nanoparticles.

HY-W040185

1,2-Dimyristoyl-sn-glycero-3-phosphate monosodium		98.0%
1,2-Dimyristoyl-sn-glycero-3-phosphate monosodium is a phospholipid containing the long-chain (14:0) myristic acid inserted at the sn-1 and sn-2 positions. It can be used in the generation of micelles, liposomes, and other types of artificial membranes.

HY-N16040

DMG-pSar25		99.0%
DMG-pSar25 is a double lipid-tailed polysarcosine lipid with 25 sarcosine moieties, serving as a PEG lipid substitute in lipid nanoparticle formulations for mRNA delivery. DMG-pSar25 supports mRNA delivery in lipid nanoparticle formulations.

HY-W598178

93-O17O		98.13%
93-O17O is a chalcogen-containing ionizable cationic lipidoid that used in the formation of lipid nanoparticles (LNPs) .

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