DSPE-PEG2000-Cy5 

DSPE-PEG2000-Cy5 is a Cy5 (HY-D0821) fluorophore-labeled conjugate of distearoylphosphatidylethanolamine and polyethylene glycol, as well as a liposome component. The Cy5 fluorophore is commonly used for labeling proteins and nucleic acids in imaging, flow cytometry and genomic applications. DSPE-PEG2000-Cy5 supports cell membrane modification, in vivo tumor targeting research and long-term in vivo circulation of its liposomal formulations (Ex/Em=633/670 nm)^[1][2].

Liposomes containing DSPE-PEG-Cy5, MW 2000 exhibits low membrane modification efficiency (≤20%) and diffuse into HepG2 cell cytoplasm by 1 h, with lower cellular fluorescence intensity compared to shorter PEG chain length variants^[1].
DSPE-PEG-Cy5, MW 2000 successfully modifies artificial cell-derived vesicles (ACDVs), and the modified vesicles are taken up by normal AML12 murine hepatocytes after 24 h of incubation^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2000 (Average)

Solid

Blue to dark blue

O=C(CCCCCCCCCCCCCCCCCCC)OC[C@](OC(CCCCCCCCCCCCCCCCCCC)=O)([H])COP(O)(OCCNC(OCCNC(CCCCC[N+]1=C(/C=C/C=C/C=C2C(C)(C)C(C=CC=C3)=C3N\2C)C(C)(C)C4=C1C=CC=C4)=O)=O)=O.[n]

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

• [1]. Ma Y, et al. A High-Efficiency Bioorthogonal Tumor-Membrane Reactor for In Situ Selective and Sustained Prodrug Activation. Angew Chem Int Ed Engl. 2024;63(10):e202318372.  [Content Brief]

  [2]. Fuji Yang, et al. Oral administration of DSPE-PEG-cholic acid-modified ACDVs loaded with siLIMA1 for anti-MASH therapy. Cell Biomaterials 1, 100129.