mGluR Modulator
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(E)-PHCCC
0 ImagesCat. No.: HY-111332CAS No.: 177610-87-6(E)-PHCCC is a positive allosteric modulator (PAM) for mGluR4, that enhances the activity of the receptor's endogenous ligand (glutamate), and exhibits activity in the calcium mobilization assay in CHO cells with an EC50 of 3.2 μM.
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DCB (Standard)
0 ImagesCat. No.: HY-103561RCAS No.: 6971-97-7DCB (Standard) is the analytical standard of DCB (HY-103561). This product is intended for research and analytical applications. DCB (3,3′-dichlorobenzaldazine) is an neutral allosteric modulator of the metabotropic glutamate receptor metabotropic glutamate receptor subtype 5 (mGluR5). DCB blocks the positive allosteric regulation of mGluRs (mGluR5) with the help of 3,3′-difluorobenzaldazine (DFB). DCB shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB).
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VU0469650 (Standard)
0 ImagesCat. No.: HY-110191RCAS No.: 1443748-47-7
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VU0422288 (Standard)
0 ImagesCat. No.: HY-110190RCAS No.: 1630936-95-6Synonyms: ML396 (Standard)VU0422288 (Standard) is the analytical standard of VU0422288 (HY-110190). This product is intended for research and analytical applications. VU0422288 (ML396) is a positive allosteric modulator of group III mGluRs. VU0422288 inhibits mGluRs with EC50s of 125 nM, 146 nM, and 108 nM for mGluR4, mGluR7, and mGluR8, respectively in calcium mobilization assays. VU0422288 reverses deficits in contextual fear memory, social recognition, and apneas in Rett syndrome (RTT) model mice.
