Acetyl octapeptide-1
Based on 1 Customer Validation
Acetyl octapeptide-1 is a competitive inhibitor of SNAP-25. Acetyl octapeptide-1 affects muscle contraction, thereby making the face (especially the forehead and periocular area) appear smoother and wrinkle-free. Acetyl octapeptide-1 can be used in research on muscle contraction and skincare products.
For research use only. We do not sell to patients.
- Purity : 99.02%
- CAS No.: 868844-74-0
- Formula: C41H70N16O16S
- Molecular Weight:1075.16
-
Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
HY-W129161
Acetyl tetrapeptide-3 -
HY-P0064
Palmitoyl Tetrapeptide-3 -
HY-W013494
L-Carnosine -
HY-P2663
Acetyl tetrapeptide-2 -
HY-W013494R
L-Carnosine (Standard) -
HY-P0045
Palmitoyl pentapeptide 4 -
HY-66015
Palmitoyl hexapeptide-12 -
HY-P0102
Dipeptide diaminobutyroyl benzylamide diacetate -
HY-125616
Biotinoyl tripeptide-1 -
HY-118060
Dipeptide 2 -
HY-118060R
Dipeptide 2 (Standard)
Biological Activity
Description
In Vitro
Acetyl octapeptide-1 (SNAP-8) (0.75-1.5 mM) acts as a competitive inhibitor of SNAP-25, decreasing neurotransmitter release with an inhibition level of 43% at 1.5 mM in an in vitro SNARE complex assay, and demonstrates synergistic effects when combined with Leuphasyl at 0.75 mM each[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 868844-74-0
-
Appearance Solid
-
Molecular Weight 1075.16
-
Formula C41H70N16O16S
-
Color White to off-white
-
Sequence
Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2
-
Sequence Shortening
Ac-EEMQRRAD-NH2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (93.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (279 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Errante F, et al. Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Frontiers in chemistry. 2020;8:572923. [Content Brief]
[2]. Shin JY, et al. Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities. Ann Dermatol. 2024 Aug;36(4):215-224. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9301 mL | 4.6505 mL | 9.3009 mL | 23.2524 mL |
| 5 mM | 0.1860 mL | 0.9301 mL | 1.8602 mL | 4.6505 mL | |
| 10 mM | 0.0930 mL | 0.4650 mL | 0.9301 mL | 2.3252 mL | |
| 15 mM | 0.0620 mL | 0.3100 mL | 0.6201 mL | 1.5502 mL | |
| 20 mM | 0.0465 mL | 0.2325 mL | 0.4650 mL | 1.1626 mL | |
| 25 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL | 0.9301 mL | |
| 30 mM | 0.0310 mL | 0.1550 mL | 0.3100 mL | 0.7751 mL | |
| 40 mM | 0.0233 mL | 0.1163 mL | 0.2325 mL | 0.5813 mL | |
| 50 mM | 0.0186 mL | 0.0930 mL | 0.1860 mL | 0.4650 mL | |
| 60 mM | 0.0155 mL | 0.0775 mL | 0.1550 mL | 0.3875 mL | |
| 80 mM | 0.0116 mL | 0.0581 mL | 0.1163 mL | 0.2907 mL |
Acetyl octapeptide-1 Related Classifications
HY-P0065 Related Classifications
Powered by Bioz