Alisol F 24-acetate
Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC50 values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research.
For research use only. We do not sell to patients.
- CAS No.: 443683-76-9
- Formula: C32H50O6
- Molecular Weight:530.74
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | EC50 |
25.29 μM
Compound: 46
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Transactivation of FXR (unknown origin) transfected in HepG2 cells co-expressing pBSEP/pGL4.74 incubated for 24 hrs by luciferase reporter gene assay
Transactivation of FXR (unknown origin) transfected in HepG2 cells co-expressing pBSEP/pGL4.74 incubated for 24 hrs by luciferase reporter gene assay
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[PMID: 31494470] |
| HepG2 2.2.15 | IC50 |
0.6 μM
Compound: 27
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Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV surface antigen secretion
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[PMID: 24549242] |
| HepG2 2.2.15 | IC50 |
5.1 μM
Compound: 27
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Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion
Antiviral activity against Hepatitis B virus infected in human HepG2.2.15 cells assessed as decrease in HBV e antigen secretion
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[PMID: 24549242] |
Alisol F 24-acetate (5, 10 and 20 µM; 24 h) increases the chemosensitivity of Doxorubicin (HY-15142A) with dose-dependent manner in MCF-7/DOX cells[2].
Alisol F 24-acetate (5, 10 and 20 µM) increases the accumulation of doxorubicin with dose-dependent manner in MCF-7/DOX cells. Alisol F 24-acetate (10 µM) increases absorption of Digoxin (HY-B1049) (AP-BL) and decreases secretion of digoxin (BL-AP) in the Caco-2 cell monolayer[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Caco-2 cells and MCF-7/DOX cells.
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Concentration:1, 2, 5, 10, 20, 50 and 100 µM.
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Incubation Time:24 h.
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Result:Significantly inhibited the cell viability (100 µM).
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Cell Line:MCF-7/DOX cells.
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Concentration:5, 10 and 20 µM.
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Incubation Time:0.5, 1, 2, 3 and 4 h.
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Result:Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.
Chemical Information
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CAS No. 443683-76-9
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Molecular Weight 530.74
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Formula C32H50O6
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SMILES
C[C@@]12[C@@]3(C(C[C@@H]([C@@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)O)=C5[C@](O[C@](C[C@H]5C)([H])[C@H](C(C)(O)C)OC(C)=O)([H])C3)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72(10):951-4. [Content Brief]
[2]. Pan G, et al. Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. Molecules. 2016 Feb 4;21(2):183. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Alisol F 24-acetate Related Classifications
HY-107315 Related Classifications
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