Alisol F 24-acetate

Cat. No.: HY-107315: FAQs
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Alisol F 24-acetate is a triterpene compound that can be isolated from the rhizomes of Alisma orientalis. Alisol F 24-acetate inhibits the secretion of HBV surface antigen HBsAg and HBeAg with IC₅₀ values of 7.7 µM and 5.1 µM. Alisol F 24-acetate has proapoptotic activity and can be used for cancer research.

For research use only. We do not sell to patients.

Alisol F 24-acetate Chemical Structure

CAS No. : 443683-76-9

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Biological Activity
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Description

In Vitro

Alisol F 24-acetate (5, 10 and 20 µM; 24 h) increases the chemosensitivity of Doxorubicin (HY-15142A) with dose-dependent manner in MCF-7/DOX cells^[2].
Alisol F 24-acetate (5, 10 and 20 µM) increases the accumulation of doxorubicin with dose-dependent manner in MCF-7/DOX cells. Alisol F 24-acetate (10 µM) increases absorption of Digoxin (HY-B1049) (AP-BL) and decreases secretion of digoxin (BL-AP) in the Caco-2 cell monolayer^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Caco-2 cells and MCF-7/DOX cells.
Concentration:	1, 2, 5, 10, 20, 50 and 100 µM.
Incubation Time:	24 h.
Result:	Significantly inhibited the cell viability (100 µM).

Apoptosis Analysis^[2]

Cell Line:	MCF-7/DOX cells.
Concentration:	5, 10 and 20 µM.
Incubation Time:	0.5, 1, 2, 3 and 4 h.
Result:	Promoted the doxorubicin-induced apoptosis with time and dose dependent manner.

Molecular Weight

530.74

Formula

C₃₂H₅₀O₆

CAS No.

443683-76-9

SMILES

C[C@@]12[C@@]3(C(C[C@@H]([C@@]1([H])[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC2)C)O)=C5[C@](O[C@](C[C@H]5C)([H])[C@H](C(C)(O)C)OC(C)=O)([H])C3)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Jiang ZY, et al. A new triterpene and anti-hepatitis B virus active compounds from Alisma orientalis. Planta Med. 2006 Aug;72(10):951-4. [Content Brief]

[2]. Pan G, et al. Alisol F 24 Acetate Enhances Chemosensitivity and Apoptosis of MCF-7/DOX Cells by Inhibiting P-Glycoprotein-Mediated Drug Efflux. Molecules. 2016 Feb 4;21(2):183. [Content Brief]